{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:13:07Z","timestamp":1772781187111,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Summary<\/jats:title>Paediatric B\u2010cell precursor acute lymphoblastic leukaemias (BCP ALL<\/jats:styled-content>) with IKZF<\/jats:styled-content>1<\/jats:italic> deletions (\u2206IKZF<\/jats:styled-content>1<\/jats:italic>) are associated with a poor outcome. However, there are conflicting data as to whether \u2206IKZF<\/jats:styled-content>1<\/jats:italic> is an independent risk factor if minimal residual disease (MRD<\/jats:styled-content>) and other copy number alterations also are taken into account. We investigated 334 paediatric BCP ALL<\/jats:styled-content>, diagnosed 1992\u20132013 and treated according to Nordic Society for Paediatric Haematology and Oncology ALL<\/jats:styled-content> protocols, with known IKZF<\/jats:styled-content>1<\/jats:italic> status based on either single nucleotide polymorphism array (N\u00a0<\/jats:italic>=\u00a0<\/jats:italic>218) or multiplex ligation\u2010dependent probe amplification (N\u00a0<\/jats:italic>=\u00a0<\/jats:italic>116) analyses. \u2206IKZF<\/jats:styled-content>1<\/jats:italic>, found in 15%, was associated with inferior 10\u2010year probabilities of event\u2010free (60% vs. 83%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001) and overall survival (pOS<\/jats:styled-content>; 73% vs. 89%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7001). Adjusting for known risk factors, including white blood cell (WBC<\/jats:styled-content>) count and MRD<\/jats:styled-content>, \u2206IKZF<\/jats:styled-content>1<\/jats:italic> was the strongest independent factor for relapse and death. \u2206IKZF<\/jats:styled-content>1<\/jats:italic> was present in 27% of cases with non\u2010informative cytogenetics (\u2018BCP<\/jats:styled-content>\u2010other\u2019) and a poor 10\u2010year pOS<\/jats:styled-content> was particularly pronounced in this group (58% vs. 90%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001). Importantly, neither MRD<\/jats:styled-content> nor WBC<\/jats:styled-content> count predicted events in the \u2206IKZF<\/jats:styled-content>1<\/jats:italic>\u2010positive cases. Co\u2010occurrence of pseudoautosomal region 1 (PAR<\/jats:styled-content>1) deletions in Xp22.33\/Yp11.32 (P2RY<\/jats:styled-content>8<\/jats:italic>\u2010CRLF<\/jats:styled-content>2<\/jats:italic>) and \u2206IKZF<\/jats:styled-content>1<\/jats:italic> increased the risk of relapse (75% vs. 30% for cases with only \u2206IKZF<\/jats:styled-content>1<\/jats:italic>; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7045), indicating that BCP<\/jats:styled-content>\u2010other ALL<\/jats:styled-content> with both P2RY<\/jats:styled-content>8<\/jats:italic>\u2010CRLF<\/jats:styled-content>2<\/jats:italic> and \u2206IKZF<\/jats:styled-content>1<\/jats:italic> constitutes a particularly high\u2010risk group.<\/jats:p>","DOI":"10.1111\/bjh.13514","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T12:28:39Z","timestamp":1432816119000},"page":"847-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The clinical impact of IKZF<\/scp>1<\/i> deletions in paediatric B\u2010cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic Society for Paediatric Haematology and Oncology treatment protocols used between 1992 and 2013"],"prefix":"10.1111","volume":"170","author":[{"given":"Linda","family":"Olsson","sequence":"first","affiliation":[{"name":"Division of Clinical Genetics Department of Laboratory Medicine Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingegerd","family":"Ivanov \u00d6fverholm","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery and Centre for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Nor\u00e9n\u2010Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Paediatrics, Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Zachariadis","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery and Centre for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Nordlund","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Sj\u00f6gren","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Transfusion Medicine Institute of Biomedicine The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Golovleva","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Medical and Clinical Genetics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Nordgren","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery and Centre for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajsa","family":"Paulsson","sequence":"additional","affiliation":[{"name":"Division of Clinical Genetics Department of Laboratory Medicine Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Heyman","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Barbany","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery and Centre for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Johansson","sequence":"additional","affiliation":[{"name":"Division of Clinical Genetics Department of Laboratory Medicine Lund University Lund Sweden"},{"name":"Department of Clinical Genetics University and Regional Laboratories Region Sk\u00e5ne Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.87"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181a1c0e8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132837"},{"key":"e_1_2_8_5_1","first-page":"1514","article-title":"Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. 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