{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:11:04Z","timestamp":1762866664672,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007052","name":"Memorial Sloan Kettering Cancer Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Few studies have examined melanoma and non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) incidence rates after a diagnosis of hairy cell leukaemia (<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>). We assessed 267 <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> patients treated at Memorial Sloan Kettering Cancer Center (<jats:styled-content style=\"fixed-case\">MSKCC<\/jats:styled-content>) and Surveillance, Epidemiology and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) data for melanoma and <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> incidence rates after <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>. Incidence data from <jats:styled-content style=\"fixed-case\">MSKCC<\/jats:styled-content> patients demonstrated a 10\u2010year combined melanoma and <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> skin cancer rate of 11\u00b73%, melanoma 4\u00b74% and <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> 6\u00b79%. Molecular analysis of skin cancers from <jats:styled-content style=\"fixed-case\">MSKCC<\/jats:styled-content> patients revealed activating <jats:italic><jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content><\/jats:italic> mutations in 3\/9 patients, including one patient with melanoma. Of 4750 <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>, 55 (1\u00b72%) had a subsequent diagnosis of melanoma. Standardized incidence ratios (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>s) did not show that melanoma was more common in <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> patients <jats:italic>versus<\/jats:italic> the general population (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> 1\u00b73, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b778\u20132\u00b703). Analysis of <jats:styled-content style=\"fixed-case\">SEER HCL<\/jats:styled-content> patients diagnosed before and after 1990 (approximately before and after purine analogue therapy was introduced) showed no evidence of an increased incidence after 1990. A better understanding of any potential association between <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> and skin cancer is highly relevant given ongoing trials using <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> inhibitors, such as vemurafenib, for relapsed <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>, as <jats:italic><jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content><\/jats:italic>\u2010mutant skin cancers could be paradoxically activated in these patients.<\/jats:p>","DOI":"10.1111\/bjh.13528","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T11:03:18Z","timestamp":1435316598000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Melanoma and non\u2010melanoma skin cancers in hairy cell leukaemia: a Surveillance, Epidemiology and End Results population analysis and the 30\u2010year experience at Memorial Sloan Kettering Cancer Center"],"prefix":"10.1111","volume":"171","author":[{"given":"Justin M.","family":"Watts","sequence":"first","affiliation":[{"name":"Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"},{"name":"Department of Medicine Division of Hematology and Oncology University of Miami Sylvester Comprehensive Cancer Center Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Kishtagari","sequence":"additional","affiliation":[{"name":"Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meier","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario E.","family":"Lacouture","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Postow","sequence":"additional","affiliation":[{"name":"Melanoma and Immunotherapeutics Service Department of Medicine Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae H.","family":"Park","sequence":"additional","affiliation":[{"name":"Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Leukemia Service Department of Medicine Memorial Sloan 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