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Increasing evidence indicates that the bone remodelling compartment (<jats:styled-content style=\"fixed-case\">BRC<\/jats:styled-content>) canopy, which normally covers the remodelling sites, is important for coupled bone remodelling. Loss of this canopy has been associated with bone loss. This study addresses whether the bone remodelling in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> is improved by high\u2010dose therapy. Bone marrow biopsies obtained from 20 <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients, before and after first\u2010line treatment with high\u2010dose melphalan followed by autologous stem cell transplantation, and from 20 control patients with monoclonal gammopathy of undetermined significance were histomorphometrically investigated. This investigation confirmed that <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients exhibited uncoupled bone formation to resorption and reduced canopy coverage. More importantly, this study revealed that a good response to anti\u2010myeloma treatment increased the extent of formative bone surfaces with canopy, and reduced the extent of eroded surfaces without canopy, reverting the uncoupled bone remodelling, while improving canopy coverage. The association between improved coupling and the canopy coverage supports the notion that canopies are critical for the coupling of bone formation to resorption. Furthermore, this study supports the observation that systemic bone disease in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> can be reversed in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients responding to anti\u2010myeloma treatment.<\/jats:p>","DOI":"10.1111\/bjh.13584","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T06:02:55Z","timestamp":1437976975000},"page":"355-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010dose therapy improves the bone remodelling compartment canopy coverage and bone formation in multiple myeloma"],"prefix":"10.1111","volume":"171","author":[{"given":"Maja","family":"Hinge","sequence":"first","affiliation":[{"name":"Department of Clinical Cell Biology Vejle\/Lillebaelt Hospital Institute of Regional Health Research University of Southern Denmark Vejle Denmark"},{"name":"Department of 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