{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:53:51Z","timestamp":1777704831956,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL088021"],"award-info":[{"award-number":["HL088021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA018029"],"award-info":[{"award-number":["CA018029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007093\u201038"],"award-info":[{"award-number":["T32 HL007093\u201038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG\u201013\u2010084\u201001\u2010CPHPS"],"award-info":[{"award-number":["RSG\u201013\u2010084\u201001\u2010CPHPS"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Haematopoietic Cell Transplantation\u2010Comorbidity Index (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) was designed as a predictor of non\u2010relapse mortality after <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. Chronic graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) contributes to mortality after <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. Here, we investigated whether the <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> could predict development of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> or post\u2010chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> mortality. We retrospectively analysed data from 2909 patients treated with allogeneic <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> for malignant and non\u2010malignant haematological conditions at four institutions. In Cox regression models adjusted for potential confounders, increasing <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> was not statistically significantly associated with the development of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> [hazard ratio (HR)\u00a0=\u00a01\u00b702, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b734]. Yet, the index was associated with an increased risk of non\u2010relapse mortality (HR\u00a0=\u00a01\u00b729, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001) as well as overall mortality (HR\u00a0=\u00a01\u00b725, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) following the development of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. The association between <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> and post\u2010chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> mortality was similar regardless of donor type or stem cell source. <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> scores could be incorporated in the design of clinical trials for treatment of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13591","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:49:07Z","timestamp":1437439747000},"page":"411-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pre\u2010transplant comorbidity burden and post\u2010transplant chronic graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"171","author":[{"given":"Jennifer E.","family":"Vaughn","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Gooley","sequence":"additional","affiliation":[{"name":"Clinical Statistics Program Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Biostatistics University of Washington School of Public Health Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Center for Hematologic Malignancies OHSU Knight Cancer Institute Portland OR USA"},{"name":"Division of Hematology and Medical Oncology Oregon Health &amp; Science University School of Medicine Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Pulsipher","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematological Malignancies Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City UT USA"},{"name":"Pediatric Blood and Marrow Transplant Program Primary Children's Hospital Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"City of Hope School of Medicine Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Maloney","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda M.","family":"Sandmaier","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Storb","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed L.","family":"Sorror","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA 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