{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:15:34Z","timestamp":1791389734037,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"crossref","award":["1090547"],"award-info":[{"award-number":["1090547"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"crossref"}]},{"name":"KinderKrebsInitiative (KKI) Buchholz\/Holm-Seppensen"},{"name":"Medical Faculty of the University","award":["F343911"],"award-info":[{"award-number":["F343911"]}]},{"name":"German Ministry of Science and Education","award":["0316166"],"award-info":[{"award-number":["0316166"]}]},{"name":"German Ministry of Science and Education","award":["031A428D"],"award-info":[{"award-number":["031A428D"]}]},{"name":"Foundation de Drie Lichten, Leiden"},{"name":"Ren\u00e9 Vogels' Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The differential diagnosis between Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) and diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) can be challenging. <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> has been reported to express less <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 than <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, but this issue has not been analysed systematically. <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> expressing <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 can be considered to be <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 co\u2010expressors, a feature that is associated with poorer outcome in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> but that has not been correlated with outcome in <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> so far. We analysed the expression of <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 in 150 cases of conventionally diagnosed <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> using two different <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 antibodies. <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 expression was detected in 23% of the cases, though the expression varied in intensity and number of positive cells. We did not detect any relevant differences in clinical presentation and outcome between <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2\u2010positive and <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2\u2010negative <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> in a subgroup of 43 cases for which detailed clinical data were available. An independent cohort of 17 <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> with expression of <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 were analysed molecularly, with 13 of 17 cases classified as molecularly defined <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> (Burkitt Lymphoma) using gene expression profiling on formalin\u2010fixed paraffin\u2010embedded tissues. The four lymphomas diagnosed molecularly as intermediates did not differ in clinical presentation and outcome from molecularly defined <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13624","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T10:21:32Z","timestamp":1437992492000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical and pathological features of Burkitt lymphoma showing expression of <scp>BCL<\/scp>2 \u2013 an analysis including gene expression in formalin\u2010fixed paraffin\u2010embedded tissue"],"prefix":"10.1111","volume":"171","author":[{"given":"Neus","family":"Masqu\u00e9\u2010Soler","sequence":"first","affiliation":[{"name":"Department of Pathology, Haematopathology Section\u00a0and Lymph Node Registry University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Szczepanowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haematopathology Section\u00a0and Lymph Node Registry University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Kohler","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sietse M.","family":"Aukema","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Spang","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics University of Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology University Children's Hospital M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haematopathology Section\u00a0and Lymph Node Registry University Hospital Schleswig\u2010Holstein Campus Kiel\/Christian\u2010Albrecht University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.02.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.091827"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-012-1719-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.281"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06194.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4342"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435842"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.43"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-460063"},{"key":"e_1_2_8_13_1","first-page":"2419","article-title":"A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. 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