{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:59:47Z","timestamp":1760299187951,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Biostatistics and Bioinformatics Shared Resource of Winship Cancer Institute of Emory University"},{"name":"NIH\/NCI","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}]},{"name":"Millennium"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bortezomib\u2010containing combinations are active in non\u2010Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) although peripheral neuropathy can limit their dose intensity. Based on our phase I findings, we conducted a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> trial of bortezomib in combination with R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) with a modified dose of vincristine. Patients with untreated indolent <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> received bortezomib (1\u00b76\u00a0mg\/m<jats:sup>2<\/jats:sup>) on days 1 and 8 of a 21\u2010day cycle for up to 8 cycles and R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> with a 1\u00b75\u00a0mg cap of vincristine. Patients achieving a complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) received maintenance rituximab, and remaining patients received maintenance rituximab and bortezomib. The primary endpoint was <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> rate; secondary survival analyses were evaluated using the Kaplan\u2013Meier method. Among 29 eligible patients, <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> morphologies included follicular (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), marginal zone (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) and small lymphocytic lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Nineteen patients had <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> (66%) and 10 had partial response (34%), yielding a 100% overall response rate. With a median follow\u2010up of 48\u00b77\u00a0months, the 4\u2010year progression\u2010free and overall survivals were 83% and 93%. Twenty\u2010two patients experienced peripheral neuropathy of any grade, and two had grade 3 neuropathy. The combination of bortezomib with R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> is effective for indolent <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>, and we plan to evaluate therapies incorporating novel proteasome inhibitors in future studies in <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13637","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:45:08Z","timestamp":1438944308000},"page":"539-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A phase <scp>II<\/scp> study of bortezomib added to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone in patients with previously untreated indolent non\u2010Hodgkin's lymphoma"],"prefix":"10.1111","volume":"171","author":[{"given":"Jonathon B.","family":"Cohen","sequence":"first","affiliation":[{"name":"Hematology and Medical Oncology Emory University Atlanta GA USA"},{"name":"Winship Cancer Institute Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean L.","family":"Koff","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Sinha","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Emory University Atlanta GA USA"},{"name":"Winship Cancer Institute Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Emory University Atlanta GA USA"},{"name":"Winship Cancer Institute Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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