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Within the latest German Hodgkin Study Group trial generation, diagnostic findings such as histopathology, computerized tomography imaging and clinical risk factors were re\u2010evaluated by expert panels. Here, we retrospectively analysed 5965 patients and identified 399 in who major discordant findings changed their first\u2010line treatment allocation. Histopathology review did not confirm the initial diagnosis of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> in 87 patients. Treatment allocation was revised in 312 of the remaining 5878 patients: 176 were assigned to a higher and 128 to a lower risk group, respectively; the correct treatment group remained unclear in 8 patients. Cases of revised treatment allocation accounted for 9\u00b78%, 6\u00b70%, 0\u00b78%, and 14\u00b78% of patients initially assigned to the <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>13, <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>14, <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>15 trials and stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> lymphocyte\u2010predominant <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> project, respectively. Most revisions were due to wrong application of clinical stage (20\u00b75% of 312 patients with revised treatment group), histological subtype (9\u00b70%) or the risk factors \u22653 involved areas (46\u00b78%) or large mediastinal mass (9\u00b73%). In conclusion, centralized review by experienced experts changed risk\u2010adapted first\u2010line treatment in a relevant proportion of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> patients. Quality control measures clearly improve the accuracy of treatment and should be implemented in clinical practice.<\/jats:p>","DOI":"10.1111\/bjh.13646","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T06:35:41Z","timestamp":1440657341000},"page":"547-556","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of centralized diagnostic review on quality of initial staging in Hodgkin lymphoma: experience of the German Hodgkin Study Group"],"prefix":"10.1111","volume":"171","author":[{"given":"Paul J.","family":"Br\u00f6ckelmann","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine University Hospital of Cologne Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Goergen","sequence":"additional","affiliation":[{"name":"German Hodgkin Study Group 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