{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:44:39Z","timestamp":1790138679021,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Grants-in-Aid for Scientific Research (JSPS KAKENHI)","award":["22591162"],"award-info":[{"award-number":["22591162"]}]},{"name":"Grants-in-Aid for Scientific Research (JSPS KAKENHI)","award":["25461597"],"award-info":[{"award-number":["25461597"]}]},{"name":"Japan Children's Cancer Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1111\/bjh.13763","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T07:10:13Z","timestamp":1443165013000},"page":"818-829","source":"Crossref","is-referenced-by-count":18,"title":["HMGA2 as a potential molecular target in<i>KMT2A-AFF1<\/i>-positive infant acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"171","author":[{"given":"Zhouying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minenori","family":"Eguchi-Ishimae","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Iwabuki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamichi","family":"Tauchi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Inukai","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; University of Yamanashi; Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; University of Yamanashi; Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics; Ehime University Graduate School of Medicine; Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"10.1111\/bjh.13763-BIB0001|bjh13763-cit-0001","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1101\/gad.510809","article-title":"The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence","volume":"23","author":"Agger","year":"2009","journal-title":"Genes & Development"},{"key":"10.1111\/bjh.13763-BIB0002|bjh13763-cit-0002","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1038\/sj.onc.1202881","article-title":"Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development","volume":"18","author":"Ayoubi","year":"1999","journal-title":"Oncogene"},{"key":"10.1111\/bjh.13763-BIB0003|bjh13763-cit-0003","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.febslet.2004.05.075","article-title":"Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2","volume":"569","author":"Brants","year":"2004","journal-title":"FEBS Letters"},{"key":"10.1111\/bjh.13763-BIB0004|bjh13763-cit-0004","first-page":"596","article-title":"Treatment of infant leukemias: challenge and promise","volume":"2013","author":"Brown","year":"2013","journal-title":"Hematology\/the Education Program of the American Society of Hematology. American Society of Hematology. Education Program"},{"key":"10.1111\/bjh.13763-BIB0005|bjh13763-cit-0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molcel.2013.12.001","article-title":"Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia","volume":"53","author":"Cao","year":"2014","journal-title":"Molecular Cell"},{"key":"10.1111\/bjh.13763-BIB0006|bjh13763-cit-0006","first-page":"289","article-title":"The HMGA proteins: a myriad of functions (Review)","volume":"32","author":"Cleynen","year":"2008","journal-title":"International Journal of Oncology"},{"key":"10.1111\/bjh.13763-BIB0007|bjh13763-cit-0007","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1158\/1541-7786.MCR-06-0331","article-title":"HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-\u03baB","volume":"5","author":"Cleynen","year":"2007","journal-title":"Molecular Cancer Research"},{"key":"10.1111\/bjh.13763-BIB0008|bjh13763-cit-0008","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/ncb2783","article-title":"The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells","volume":"15","author":"Copley","year":"2013","journal-title":"Nature Cell Biology"},{"key":"10.1111\/bjh.13763-BIB0009|bjh13763-cit-0009","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1182\/blood-2013-04-497644","article-title":"Potent inhibition of DOT1L as treatment of MLL-fusion leukemia","volume":"122","author":"Daigle","year":"2013","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0010|bjh13763-cit-0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10509","article-title":"Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia","volume":"478","author":"Dawson","year":"2011","journal-title":"Nature"},{"key":"10.1111\/bjh.13763-BIB0011|bjh13763-cit-0011","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.yexcr.2012.04.018","article-title":"Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines","volume":"318","author":"Fazio","year":"2012","journal-title":"Experimental Cell Research"},{"key":"10.1111\/bjh.13763-BIB0012|bjh13763-cit-0012","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1182\/blood-2003-11-3817","article-title":"The small oligomerization domain of gephyrin converts MLL to an oncogene","volume":"103","author":"Eguchi","year":"2004","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0013|bjh13763-cit-0013","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/leu.2013.173","article-title":"Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia","volume":"27","author":"Estey","year":"2013","journal-title":"Leukemia"},{"key":"10.1111\/bjh.13763-BIB0014|bjh13763-cit-0014","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbagrm.2009.11.007","article-title":"HMGA and cancer","volume":"1799","author":"Fedele","year":"2010","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1111\/bjh.13763-BIB0015|bjh13763-cit-0015","first-page":"899","article-title":"Roles of HMGA proteins in cancer","volume":"7","author":"Fusco","year":"2007","journal-title":"Nature Reviews: Cancer"},{"key":"10.1111\/bjh.13763-BIB0016|bjh13763-cit-0016","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nchembio.773","article-title":"Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia","volume":"8","author":"Grembecka","year":"2012","journal-title":"Nature Chemical Biology"},{"key":"10.1111\/bjh.13763-BIB0017|bjh13763-cit-0017","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2008.11.026","article-title":"HMGA2, microRNAs, and stem cell aging","volume":"135","author":"Hammond","year":"2008","journal-title":"Cell"},{"key":"10.1111\/bjh.13763-BIB0018|bjh13763-cit-0018","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/bjh.13129","article-title":"Dysregulation of the MIRLET7\/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms","volume":"168","author":"Harada-Shirado","year":"2015","journal-title":"British Journal of Haematology"},{"key":"10.1111\/bjh.13763-BIB0019|bjh13763-cit-0019","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00384-009-0770-7","article-title":"Gene expressions of HMGI-C and HMGI(Y) are associated with stage and metastasis in colorectal cancer","volume":"24","author":"Huang","year":"2009","journal-title":"International Journal of Colorectal Disease"},{"key":"10.1111\/bjh.13763-BIB0020|bjh13763-cit-0020","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/sj.leu.2401893","article-title":"Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome","volume":"14","author":"Iijima","year":"2000","journal-title":"Leukemia"},{"key":"10.1111\/bjh.13763-BIB0021|bjh13763-cit-0021","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/sj.leu.2400951","article-title":"Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF","volume":"12","author":"Inukai","year":"1998","journal-title":"Leukemia"},{"key":"10.1111\/bjh.13763-BIB0022|bjh13763-cit-0022","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1158\/0008-5472.CAN-08-2739","article-title":"DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation","volume":"69","author":"Kotake","year":"2009","journal-title":"Cancer Research"},{"key":"10.1111\/bjh.13763-BIB0023|bjh13763-cit-0023","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1182\/blood-2014-02-554543","article-title":"Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice","volume":"124","author":"Lam","year":"2014","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0024|bjh13763-cit-0024","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/gad.1540407","article-title":"The tumor suppressor microRNA let-7 represses the HMGA2 oncogene","volume":"21","author":"Lee","year":"2007","journal-title":"Genes & Development"},{"key":"10.1111\/bjh.13763-BIB0025|bjh13763-cit-0025","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1182\/blood-2013-04-493916","article-title":"G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia","volume":"123","author":"Lee","year":"2014a","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0026|bjh13763-cit-0026","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbagrm.2014.02.017","article-title":"The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein","volume":"1839","author":"Lee","year":"2014b","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1111\/bjh.13763-BIB0027|bjh13763-cit-0027","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.devcel.2012.10.019","article-title":"An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis","volume":"23","author":"Li","year":"2012","journal-title":"Developmental Cell"},{"key":"10.1111\/bjh.13763-BIB0028|bjh13763-cit-0028","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1158\/0008-5472.CAN-12-3947","article-title":"Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway","volume":"73","author":"Li","year":"2013","journal-title":"Cancer Research"},{"key":"10.1111\/bjh.13763-BIB0029|bjh13763-cit-0029","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1182\/blood-2014-04-572958","article-title":"RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence","volume":"124","author":"Lie","year":"2014","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0030|bjh13763-cit-0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2141.2010.08459.x","article-title":"Mechanisms of leukemogenesis by MLL fusion proteins","volume":"152","author":"Marschalek","year":"2011","journal-title":"British Journal of Haematology"},{"key":"10.1111\/bjh.13763-BIB0031|bjh13763-cit-0031","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"},{"key":"10.1111\/bjh.13763-BIB0032|bjh13763-cit-0032","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ab.2007.10.023","article-title":"Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay","volume":"374","author":"Miao","year":"2008","journal-title":"Analytical Biochemistry"},{"key":"10.1111\/bjh.13763-BIB0033|bjh13763-cit-0033","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.leu.2401437","article-title":"p16\/MTS1\/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation","volume":"13","author":"Nakamura","year":"1999","journal-title":"Leukemia"},{"key":"10.1111\/bjh.13763-BIB0034|bjh13763-cit-0034","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI69739","article-title":"Clinical development of demethylating agents in hematology","volume":"124","author":"Navada","year":"2014","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1111\/bjh.13763-BIB0035|bjh13763-cit-0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/leu.2012.242","article-title":"Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements","volume":"27","author":"Nishi","year":"2013","journal-title":"Leukemia"},{"key":"10.1111\/bjh.13763-BIB0036|bjh13763-cit-0036","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","article-title":"Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression","volume":"135","author":"Nishino","year":"2008","journal-title":"Cell"},{"key":"10.1111\/bjh.13763-BIB0037|bjh13763-cit-0037","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fmed.2015.00015","article-title":"High mobility group a proteins as tumor markers","volume":"2","author":"Pallante","year":"2015","journal-title":"Frontiers in Medicine"},{"key":"10.1111\/bjh.13763-BIB0038|bjh13763-cit-0038","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/BF00360537","article-title":"Hoechst 33258, distamycin A, and high mobility group protein I (HMG-I) compete for binding to mouse satellite DNA","volume":"101","author":"Radic","year":"1992","journal-title":"Chromosoma"},{"key":"10.1111\/bjh.13763-BIB0039|bjh13763-cit-0039","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1016\/S0021-9258(19)38926-4","article-title":"The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure","volume":"265","author":"Reeves","year":"1990","journal-title":"Journal of Biological Chemistry"},{"key":"10.1111\/bjh.13763-BIB0040|bjh13763-cit-0040","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1111\/bjh.13763-BIB0041|bjh13763-cit-0041","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/10428199709050896","article-title":"HMGI-C, a member of the high mobility group family of proteins, is expressed in hematopoietic stem cells and in leukemic cells","volume":"26","author":"Rommel","year":"1997","journal-title":"Leukaemia & Lymphoma"},{"key":"10.1111\/bjh.13763-BIB0042|bjh13763-cit-0042","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/bbrc.1999.1680","article-title":"Sp1 and CTF\/NF-1 transcription factors are involved in the basal expression of the Hmgi-c proximal promoter","volume":"265","author":"Rustighi","year":"1999","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1111\/bjh.13763-BIB0043|bjh13763-cit-0043","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1182\/blood-2009-09-243634","article-title":"Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting","volume":"115","author":"Schafer","year":"2010","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0044|bjh13763-cit-0044","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3324\/haematol.2010.026138","article-title":"MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia","volume":"96","author":"Schotte","year":"2011","journal-title":"Haematologica"},{"key":"10.1111\/bjh.13763-BIB0045|bjh13763-cit-0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.stem.2013.03.005","article-title":"Lin28: primal regulator of growth and metabolism in stem cells","volume":"12","author":"Shyh-Chang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1111\/bjh.13763-BIB0046|bjh13763-cit-0046","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2004-09-3667","article-title":"Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia","volume":"106","author":"Stam","year":"2005","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0047|bjh13763-cit-0047","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1182\/blood-2009-07-233049","article-title":"Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants","volume":"115","author":"Stam","year":"2010","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0048|bjh13763-cit-0048","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.1305172110","article-title":"HMGA2\/TET1\/HOXA9 signaling pathway regulates breast cancer growth and metastasis","volume":"110","author":"Sun","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1111\/bjh.13763-BIB0049|bjh13763-cit-0049","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.stem.2008.10.008","article-title":"Ink4a\/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging","volume":"3","author":"Tzatsos","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1111\/bjh.13763-BIB0050|bjh13763-cit-0050","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood-2002-06-1770","article-title":"TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells","volume":"101","author":"Uno","year":"2003","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0051|bjh13763-cit-0051","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nature07284","article-title":"Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy","volume":"455","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"10.1111\/bjh.13763-BIB0052|bjh13763-cit-0052","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1158\/1078-0432.CCR-10-2542","article-title":"Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers","volume":"17","author":"Wang","year":"2011","journal-title":"Clinical Cancer Research"},{"key":"10.1111\/bjh.13763-BIB0053|bjh13763-cit-0053","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.celrep.2012.12.016","article-title":"RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction","volume":"3","author":"Wilkinson","year":"2013","journal-title":"Cell Reports"},{"key":"10.1111\/bjh.13763-BIB0054|bjh13763-cit-0054","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1158\/1078-0432.CCR-05-1853","article-title":"Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer","volume":"12","author":"Xi","year":"2006","journal-title":"Clinical Cancer Research"},{"key":"10.1111\/bjh.13763-BIB0055|bjh13763-cit-0055","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1182\/blood-2014-06-581082","article-title":"Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia","volume":"125","author":"Xu","year":"2015","journal-title":"Blood"},{"key":"10.1111\/bjh.13763-BIB0056|bjh13763-cit-0056","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1093\/nar\/24.20.4071","article-title":"Genomic structure and expression of the murine Hmgi-c gene","volume":"24","author":"Zhou","year":"1996","journal-title":"Nucleic Acids Research"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13763","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/bjh.13763\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T07:16:20Z","timestamp":1653203780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,25]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1111\/bjh.13763","archive":["Portico"],"relation":{},"ISSN":["0007-1048"],"issn-type":[{"value":"0007-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9,25]]}}}