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In the past 10\u00a0years the pathophysiology of this condition has been defined as JAK\/STAT pathway activation, almost always due to mutations in <jats:italic>JAK2<\/jats:italic> exons 12 or 14 (<jats:italic>JAK2<\/jats:italic> V617F). In the same time period our understanding of the optimal management of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> has expanded, most recently culminating in the approval of <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content> inhibitors for the treatment of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients who are resistant or intolerant to therapy with hydroxycarbamide. It has also been demonstrated that life expectancy for many patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> is not normal, nor is their quality of life. We critically explore these findings and discuss their impact. In addition, we highlight persisting gaps in our current management strategy; for example, what is the optimal first line cytoreductive therapy and, indeed, which patients need cytoreductive drugs.<\/jats:p>","DOI":"10.1111\/bjh.13812","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T13:37:21Z","timestamp":1445607441000},"page":"337-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Management of polycythaemia vera: a critical review of current data"],"prefix":"10.1111","volume":"172","author":[{"given":"Mary F.","family":"McMullin","sequence":"first","affiliation":[{"name":"Centre for Cancer Research and Cell Biology Queen's University Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget S.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Departments of Cellular Pathology and Haematology Guy's and St Thomas\u2019 NHS 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