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We report the treatment outcomes and toxicity profiles observed in <jats:styled-content style=\"fixed-case\">TYA<\/jats:styled-content> patients treated on the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> paediatric <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> trial, <jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content>2003. <jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content>2003 was a multi\u2010centre, prospective, randomized phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> trial, investigating treatment intensification or de\u2010escalation according to minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) kinetics at the end of induction. Of 3126 patients recruited to <jats:styled-content style=\"fixed-case\">UKALL<\/jats:styled-content>2003, 229 (7\u00b73%) were aged 16\u201324\u00a0years. These patients were significantly more likely to have high risk <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> compared to 10\u201315\u00a0year olds (47\u00b79% vs. 36\u00b76%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). Nonetheless, 5\u2010year event\u2010free survival for the <jats:styled-content style=\"fixed-case\">TYA<\/jats:styled-content> cohort (aged 16\u201324\u00a0years) was 72\u00b73% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 66\u00b72\u201378\u00b74] overall and 92\u00b76% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 85\u00b75\u201399\u00b77) for <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> low risk patients. The risk of serious adverse events was higher in patients aged \u226510\u00a0years compared to those aged 9 or younger (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) and novel age\u2010specific patterns of treatment\u2010related toxicity were observed. <jats:styled-content style=\"fixed-case\">TYA<\/jats:styled-content> patients obtain excellent outcomes with a risk\u2010 and response\u2010adapted paediatric chemotherapy protocol. Whilst those aged 10\u00a0years and older have excess toxicity compared with younger patients, the age association is specific to individual toxicities.<\/jats:p>","DOI":"10.1111\/bjh.13847","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T01:11:28Z","timestamp":1450487488000},"page":"439-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Efficacy and toxicity of a paediatric protocol in teenagers and young adults with Philadelphia chromosome negative acute lymphoblastic leukaemia: results from <scp>UKALL<\/scp> 2003"],"prefix":"10.1111","volume":"172","author":[{"given":"Rachael","family":"Hough","sequence":"first","affiliation":[{"name":"University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Rowntree","sequence":"additional","affiliation":[{"name":"University Hospital of Wales Cardiff 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