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However, early relapse and refractoriness are current limitations of <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> treatment and new biological factors affecting the outcome of these patients have not been explored. This study aimed to identify the presence of genomic changes that could predict the response to new therapies in <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>. Forty adolescent and adult <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> patients treated with the Dose\u2010Intensive Chemotherapy Including Rituximab (Burkimab) protocol (Spanish Programme for the Study and Treatment of Haematological Malignancies; <jats:styled-content style=\"fixed-case\">PETHEMA<\/jats:styled-content>) were analysed using array\u2010based comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>). In addition, the presence of <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53, <jats:styled-content style=\"fixed-case\">TCF<\/jats:styled-content>3 (E2A), <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">GNA<\/jats:styled-content>13<\/jats:italic> mutations was assessed by next\u2010generation sequencing (<jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>). Ninety\u2010seven per cent of the patients harboured genomic imbalances. Losses on 11q, 13q, 15q or 17p were associated with a poor response to Burkimab therapy (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7038), shorter progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>;<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7007) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>;<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7009). The integrative analysis of array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content> showed that 26\u00b73% (5\/19) and 36\u00b78% (7\/19) of patients carried alterations in the <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TCF<\/jats:styled-content>3<\/jats:italic> genes, respectively. <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> alterations were associated with shorter <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7011) while <jats:italic><jats:styled-content style=\"fixed-case\">TCF<\/jats:styled-content>3<\/jats:italic> alterations were associated with shorter <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b7032). Genetic studies could be used for risk stratification of <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> patients treated with the Burkimab protocol.<\/jats:p>","DOI":"10.1111\/bjh.13849","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T10:46:45Z","timestamp":1447670805000},"page":"428-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose\u2010intensive chemotherapy including rituximab"],"prefix":"10.1111","volume":"172","author":[{"given":"Maribel","family":"Forero\u2010Castro","sequence":"first","affiliation":[{"name":"Cancer Research Centre IBSAL IBMCC University of Salamanca CSIC Salamanca Spain"},{"name":"School of Biological Sciences (GEBIMOL) Pedagogical and Technological University of Colombia (UPTC) Colombia IN 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