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At subsequent relapse, Case 10, with 6 <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010specific lesions, and Case 100, with 6 <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010specific and 8 <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\u2010specific lesions, showed, in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>, the clonal expansion of <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010derived lesions with an adverse impact: <jats:italic><jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>3B1<\/jats:italic> mutation, <jats:italic><jats:styled-content style=\"fixed-case\">BIRC<\/jats:styled-content>3<\/jats:italic> deletion<jats:italic>,<\/jats:italic> del8(p23\u00b73\u2010p11\u00b71), del9(p24\u00b73\u2010p13\u00b71) and gain 2(p25\u00b73\u2010p14). <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> shows an intra\u2010patient clonal heterogeneity according to the disease compartment, with both <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\u2010specific mutations\/<jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s. The <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> microenvironment might contribute to the clonal selection of unfavourable lesions, as <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010derived mutations\/<jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s can appear in the <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> at relapse.<\/jats:p>","DOI":"10.1111\/bjh.13859","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T06:00:52Z","timestamp":1448344852000},"page":"371-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Inter\u2010 and intra\u2010patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments"],"prefix":"10.1111","volume":"172","author":[{"given":"Ilaria","family":"Del 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