{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:57:44Z","timestamp":1779188264971,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR\u20102010\u20102313609"],"award-info":[{"award-number":["GR\u20102010\u20102313609"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 14797\u20102013"],"award-info":[{"award-number":["IG 14797\u20102013"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic\/recurrent behaviour may be encountered in some distinct atypical or malignant lymphoproliferations, while recurrences are not generally observed in reactive\/benign lymphadenopathies. We retrospectively analysed a consecutive series of 486 human immunodeficiency virus\u2010negative adults, who underwent lymphadenectomy. Neoplastic and benign\/reactive histopathological pictures were documented in 299 (61\u00b75%) and 187 (38\u00b75%) cases, respectively. Of note, seven of the 111 (6\u00b73%) patients with benign lymphadenopathy without well\u2010defined aetiology, showed chronic\/recurrent behaviour, without constitutional symptoms. Enlarged lymph nodes were round in shape and hypoechoic, mimicking lymphoma. Reactive follicular hyperplasia and paracortical expansion were observed. Human herpesvirus (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>)\u20106B positive staining in follicular dendritic cells (<jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content>s) was documented in all seven patients. Serological, molecular and immunological examinations suggested <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106B reactivation. Among the remaining 104 cases with reactive lymphoid hyperplasia in the absence of well\u2010known aetiology and without recurrences, positivity for <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106B on <jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content>s was found in three cases, whereas in seven further patients, a scanty positivity was documented in rare, scattered cells in inter\u2010follicular regions. Immunohistochemistry for <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106A and <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106B was invariably negative on 134 lymph nodes, with either benign pictures with known aetiology or malignant lymphoproliferative disorders, tested as further controls. Future studies are warranted to investigate a potential association between <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106B reactivation and chronic\/recurrent benign lymphadenopathy.<\/jats:p>","DOI":"10.1111\/bjh.13871","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T01:11:03Z","timestamp":1450487463000},"page":"561-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus\u20106B reactivation"],"prefix":"10.1111","volume":"172","author":[{"given":"Fabio","family":"Forghieri","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Luppi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Barozzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Riva","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Morselli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Quadrelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vallerini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Maccaferri","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Coluccio","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambra","family":"Paolini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Colaci","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goretta","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Maiorana","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Tagliazucchi","sequence":"additional","affiliation":[{"name":"Dipartimento Integrato di Medicina di Laboratorio Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rumpianesi","sequence":"additional","affiliation":[{"name":"Dipartimento Integrato di Medicina di Laboratorio Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Presutti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Gelmini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Cermelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dipartimento Integrato di Medicina di Laboratorio Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Comoli","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Marasca","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Narni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Potenza","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Materno Infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Azienda Ospedaliero\u2010Universitaria Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21860"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1902-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290304"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290304"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.12.001"},{"key":"e_1_2_8_7_1","first-page":"3413","article-title":"HHV\u20106\u2010associated acute lymphadenitis in immunocompetent patients: a case report and review of literature","volume":"7","author":"Bai Y.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm862"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.08.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-4-406"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600738"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01358.x"},{"key":"e_1_2_8_13_1","first-page":"1313","article-title":"Lymphadenopathy: differential diagnosis and evaluation","volume":"58","author":"Ferrer R.","year":"1998","journal-title":"American Family Physician"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199203000-00005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903528286"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430413"},{"key":"e_1_2_8_17_1","first-page":"242","article-title":"Diagnostic approach to lymph node enlargement","volume":"84","author":"Ghirardelli M.L.","year":"1999","journal-title":"Haematologica\/the Haematology Journal"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.04.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.06.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107819\u20109\u201029"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0470"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1173"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/342962"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.162"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(93)90049-Q"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65623-4"},{"key":"e_1_2_8_27_1","first-page":"967","volume-title":"Clinical Hematology","author":"Maciejewski J.P.","year":"2006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800179"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00319-W"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21767"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92783-3"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.49.57"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-280347"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20443"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074479"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02685.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-366526"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.10.005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.958"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24234"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09206.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2009.2469"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.6.776"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1992.tb02047.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.12.1137"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1182\/blood.V77.10.2251.2251","article-title":"Human herpesvirus\u20106 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction","volume":"77","author":"Torelli G.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.11.008"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890390109"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.176"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042207"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06620.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13871","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:59:32Z","timestamp":1696258772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/bjh.13871"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13871","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]},"assertion":[{"value":"2015-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}