{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:33:06Z","timestamp":1787866386593,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Genentech Inc.\/F. Hoffmann-La Roche Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To examine the effectiveness of an initial management strategy of watchful waiting for follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) in clinical practice, we compared outcomes for patients diagnosed 2004\u20132007 in the United States initially managed with watchful waiting with outcomes following initial rituximab monotherapy and chemoimmunotherapy. In total, 1754 stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> patients in the National LymphoCare Study underwent watchful waiting (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>386), rituximab monotherapy (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>296) or rituximab plus chemotherapy (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1072) as initial management strategy. Female patients and those who received treatment in the Northeast or in an academic setting more commonly underwent watchful waiting <jats:italic>versus<\/jats:italic> initial chemoimmunotherapy; whereas patients with grade 3 histology, anaemia, elevated lactate dehydrogenase, extranodal involvement, B symptoms or performance status \u22651 more commonly received chemoimmunotherapy. Although time to new treatment and progression\u2010free survival following first\u2010 and second\u2010line therapy were improved with chemoimmunotherapy, and time to chemotherapy was improved with rituximab monotherapy, there were no differences in overall survival between watchful waiting and chemoimmunotherapy or rituximab monotherapy. With 8\u2010year overall survival estimates of 74%, initial management with watchful waiting in the context of sequential therapy remains a viable option for <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients in the modern era. This trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00097565).<\/jats:p>","DOI":"10.1111\/bjh.13895","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T08:44:42Z","timestamp":1451983482000},"page":"724-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Outcomes following watchful waiting for stage <scp>II<\/scp>\u2013<scp>IV<\/scp> follicular lymphoma patients in the modern era"],"prefix":"10.1111","volume":"172","author":[{"given":"Loretta J.","family":"Nastoupil","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Sinha","sequence":"additional","affiliation":[{"name":"University Oncology &amp; Hematology Associates Chattanooga TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Byrtek","sequence":"additional","affiliation":[{"name":"Genentech\/Roche South San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Ziemiecki","sequence":"additional","affiliation":[{"name":"Biostatistics RTI Health Solutions Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biostatistics RTI Health Solutions Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Taylor","sequence":"additional","affiliation":[{"name":"Genentech\/Roche South San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"James P. 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