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The current key components of treatment are intensive polychemotherapy and a <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> kinase domain inhibitor. This treatment approach has been applied in a few clinical trials by paediatric leukaemia study groups. Thus, this subtype of <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> serves as the first model system for truly targeted treatment. The role of haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) is increasingly called into question, at least in a favourable, though not yet clearly defined, subset of patients. 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