{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:30:56Z","timestamp":1789644656396,"version":"4.0.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012353","name":"German Cancer Consortium","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012353","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>Treatment success in patients with acute myeloid leukaemia (AML<\/jats:styled-content>) is heterogeneous. Cytogenetic and molecular alterations are strong prognostic factors, which have been used to individualize treatment. Here, we studied the impact of TP<\/jats:styled-content>53<\/jats:italic> mutations on the outcome of AML<\/jats:styled-content> patients with adverse cytogenetic risk treated with allogeneic haematopoietic stem cell transplantation (HSCT<\/jats:styled-content>). Samples of 97 patients with AML<\/jats:styled-content> and adverse\u2010risk cytogenetics who had received a HSCT<\/jats:styled-content> within three randomized trials were analysed. Complete sequencing of the TP<\/jats:styled-content>53<\/jats:italic> coding region was performed using next generation sequencing. The median age was 51\u00a0years. Overall, TP<\/jats:styled-content>53<\/jats:italic> mutations were found in 40 patients (41%). With a median follow up of 67\u00a0months, the three\u2010year probabilities of overall survival (OS<\/jats:styled-content>) and event\u2010free survival for patients with TP<\/jats:styled-content>53<\/jats:italic> wild type were 33% [95% confidence interval (CI<\/jats:styled-content>), 21% to 45%] and 24% (95% CI<\/jats:styled-content>, 13% to 35%) compared to 10% (95% CI<\/jats:styled-content>, 0% to 19%) and 8% (95% CI<\/jats:styled-content>, 0% to 16%) (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7002 and P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7007) for those with mutated TP<\/jats:styled-content>53,<\/jats:italic> respectively. In multivariate analysis, the TP<\/jats:styled-content>53<\/jats:italic>\u2010mutation status had a negative impact on OS<\/jats:styled-content> (Hazard Ratio\u00a0=\u00a01\u00b77; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7066). Mutational analysis of TP<\/jats:styled-content>53<\/jats:italic> might be an important additional tool to predict outcome after HSCT<\/jats:styled-content> in patients with adverse karyotype AML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13912","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T09:41:46Z","timestamp":1452764506000},"page":"914-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["TP<\/scp>53<\/i> mutation in patients with high\u2010risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"172","author":[{"given":"Jan M.","family":"Middeke","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Herold","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"},{"name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung Deutsches Krebsforschungszentrum Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"R\u00fccker\u2010Braun","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik A Universit\u00e4tsklinikum M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stelljes","sequence":"additional","affiliation":[{"name":"Medizinische Klinik A Universit\u00e4tsklinikum M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Robert Bosch Hospital Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sch\u00e4fer\u2010Eckart","sequence":"additional","affiliation":[{"name":"Klinikum Nord N\u00fcrnberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Baldus","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reingard","family":"Stuhlmann","sequence":"additional","affiliation":[{"name":"Asklepios Klinik St Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik Abteilung Innere Medizin V, H\u00e4matologie, Onkologie und Rheumatologie Universit\u00e4t Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II Universit\u00e4tsklinikum W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf","family":"R\u00f6sler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 5 Universit\u00e4tsklinikum Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Serve","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II Klinikum der J.W. Goethe Universit\u00e4t Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"H\u00e4nel","sequence":"additional","affiliation":[{"name":"Klinikum Chemnitz gGmbH Klinik f\u00fcr Innere Medizin III Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sohlbach","sequence":"additional","affiliation":[{"name":"Kliniken f\u00fcr Innere Medizin, H\u00e4matologie\/Onkologie und Immunologie Universit\u00e4tsklinikum Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klesse","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Centre Clinical Trials Unit Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Mohr","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"R\u00f6llig","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Ehninger","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thiede","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"},{"name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung Deutsches Krebsforschungszentrum Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schetelig","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus der TU Dresden Dresden Germany"},{"name":"DKMS German Bone Marrow Donor Centre Clinical Trials Unit Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Study Alliance Leukaemia (SAL)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.03.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582809"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235358"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.1.349"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-126508"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-419622"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.143"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.743.743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-544957"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12253"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.104760"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0609"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.26"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-267302"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401913"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375758"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7303"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.4743"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100674"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2191-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.375"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35106009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045820"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2584"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13968"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:20:04Z","timestamp":1696299604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/bjh.13912"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13912","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]},"assertion":[{"value":"2015-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}