{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:06:16Z","timestamp":1777701976819,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Salus Sanguinis Foundation"},{"name":"Fonds Maisin"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise des Cancers de l'Enfant (SFCE)"},{"name":"Belgian Fonds National de la Recherche Scientifique"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Dysregulation of <jats:italic>MYC<\/jats:italic> is the genetic hallmark of Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) but it is encountered in other aggressive mature B\u2010cell lymphomas. <jats:italic>MYC<\/jats:italic> dysregulation needs other cooperating events for <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> development. We aimed to characterize these events and assess the differences between adult and paediatric <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s that may explain the different outcomes in these two populations. We analysed patterns of genetic aberrations in a series of 24 BLs: 11 adults and 13 children. We looked for genomic imbalances (copy number variations), copy\u2010neutral loss of heterozygosity (<jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>) and mutations in <jats:italic>TP53<\/jats:italic>,<jats:italic> CDKN2A<\/jats:italic>,<jats:italic> ID3<\/jats:italic> (exon 1), <jats:italic>TCF3<\/jats:italic> (exon17) and <jats:italic>CCND3<\/jats:italic> (exon 6). Young patients displayed more frequent 13q31.3q32.1 amplification, 7q32q36 gain and 5q23.3 CN\u2010<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>, while 17p13 and 18q21.3 <jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> were only detected in adult <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s. <jats:italic><jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>3<\/jats:italic> mutations were present in all adult samples, but only in 42% of childhood cases. <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>3<\/jats:italic> double\u2010hit mutations, as well as 18q21 <jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>, seemed to be associated with poorer outcome. For the first time, we report different genetic anomalies between adult and paediatric <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s, suggesting age\u2010related heterogeneity in Burkitt lymphomagenesis. This may explain the poorer prognosis of adult <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s. Additional studies are needed to confirm these results in the setting of clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.13925","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T19:01:56Z","timestamp":1455822116000},"page":"137-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genetic differences between paediatric and adult Burkitt lymphomas"],"prefix":"10.1111","volume":"173","author":[{"given":"Violaine","family":"Havelange","sequence":"first","affiliation":[{"name":"Department of Haematology Cliniques universitaires Saint\u2010Luc \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Pepermans","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics Cliniques universitaires Saint\u2010Luc \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Ameye","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics Cliniques universitaires Saint\u2010Luc \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Th\u00e9ate","sequence":"additional","affiliation":[{"name":"Department of Pathology Cliniques universitaires Saint\u2010Luc, Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Callet\u2010Bauchu","sequence":"additional","affiliation":[{"name":"Laboratoire central d'H\u00e9matologie CHU Lyon\u2010Sud Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Barin","sequence":"additional","affiliation":[{"name":"Laboratoire de Cytog\u00e9n\u00e9tique CHU Bretonneau Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Penther","sequence":"additional","affiliation":[{"name":"Laboratoire de g\u00e9n\u00e9tique oncologique Centre Henri Becquerel Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lippert","sequence":"additional","affiliation":[{"name":"Laboratoire d'h\u00e9matologie CHU Bordeaux Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Michaux","sequence":"additional","affiliation":[{"name":"Centrum voor menselijke erfelijkheid Katholieke Universiteit Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Mugneret","sequence":"additional","affiliation":[{"name":"Laboratoire de Cytog\u00e9n\u00e9tique CHU Dijon Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Dastugue","sequence":"additional","affiliation":[{"name":"G\u00e9n\u00e9tique des h\u00e9mopathies H\u00f4pital Purpan Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Rapha\u00ebl","sequence":"additional","affiliation":[{"name":"Anatomie et cytologie pathologiques CHU Bic\u00eatre \u2013Assistance Publique\u2010H\u00f4pitaux de Paris INSERM U802 Universit\u00e9 Paris\u2010Sud 11 Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miikka","family":"Vikkula","sequence":"additional","affiliation":[{"name":"Human Molecular Genetics (GEHU) de Duve Institute \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne A.","family":"Poirel","sequence":"additional","affiliation":[{"name":"Department of Haematology Cliniques universitaires Saint\u2010Luc \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"},{"name":"Human Molecular Genetics (GEHU) de Duve Institute \u2013 Universit\u00e9 catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.12.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365898"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3369"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.02974.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-349662"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi403"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08918.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437624"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000059"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563627"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-538504"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.178"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.8052"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136465"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388470"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2468"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.08.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5827"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.34"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12054"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-9-34"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.312"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2469"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.06.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08883.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11378"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014282"},{"key":"e_1_2_7_32_1","volume-title":"ISCN (2013): An International System for Human Cytogenetic Nomenclature","author":"Shaffer L.G.","year":"2013"},{"key":"e_1_2_7_33_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S.H.","year":"2008"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13925","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:26:40Z","timestamp":1696325200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/bjh.13925"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13925","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]},"assertion":[{"value":"2015-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}