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Although the first cord blood transplants were done in children, there are currently more cord blood transplants performed in adults. In this review, we explore the history of umbilical cord blood transplantation, paediatric and adult outcome results, and novel trends to improve engraftment and reduce infection. Umbilical cord blood transplantation cures approximately 30\u201340% of adults and 60\u201370% of children with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>. Controversial issues, including the use of double <jats:italic>versus<\/jats:italic> single cord blood units for transplantation, optimal cord blood unit selection, infection prophylaxis, conditioning regimens and graft versus host disease prophylaxis, will be reviewed. Finally, comparison to other graft sources, cost, access to care, and the ideal graft source are discussed.<\/jats:p>","DOI":"10.1111\/bjh.13926","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T10:36:33Z","timestamp":1452767793000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cord blood transplant for acute myeloid leukaemia"],"prefix":"10.1111","volume":"173","author":[{"given":"Karen K.","family":"Ballen","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Seidman Cancer Center Case Western Reserve University Cleveland OH 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