{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:45:47Z","timestamp":1790786747689,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Campus Hungary Short Term Study Program"},{"name":"Region Guadeloupe"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vaso\u2010occlusive crisis (<jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>) is the main acute complication in sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) and several clinical trials are investigating different drugs to improve the clinical severity of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients. A phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> study is currently exploring the profit of Velopoloxamer in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>s. We analysed, <jats:italic>in\u2010vitro<\/jats:italic>, the effect of poloxamer (P188) on red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) properties by investigating haemorheology, mechanical and adhesion functions using ektacytometry, microfluidics and dynamic adhesion approaches, respectively. We show that poloxamer significantly reduces blood viscosity, <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> aggregation and adhesion to endothelial cells, supporting the beneficial use of this molecule in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/bjh.13937","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T08:32:00Z","timestamp":1454661120000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia"],"prefix":"10.1111","volume":"173","author":[{"given":"Barbara","family":"Sandor","sequence":"first","affiliation":[{"name":"University of Pecs Medical School Pecs 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