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Anthracyline\u2010based treatment is standard in resource\u2010rich settings, but has not been described in <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>. Children \u226418\u00a0years of age with newly diagnosed <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> were prospectively enrolled from June 2013 to May 2015 in Malawi. Staging and supportive care were standardized, as was treatment with <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. Among 73 children with <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>, median age was 9\u00b72\u00a0years (interquartile range 7\u00b77\u201311\u00b78), 48 (66%) were male and two were positive for human immunodeficiency virus. Twelve (16%) had stage I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disease, 36 (49%) stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and 25 (34%) stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Grade 3\/4 neutropenia occurred in 17 (25%), and grade 3\/4 anaemia in 29 (42%) of 69 evaluable children. Eighteen\u2010month overall survival was 29% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 18\u201341%) overall. Mortality was associated with age &gt;9\u00a0years [hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 2\u00b713, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b715\u20133\u00b794], female gender (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2\u00b712, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b712\u20134\u00b703), stage (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1\u00b752 per unit, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b707\u20132\u00b717), lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1\u00b703 per 100\u00a0iu\/l, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b701\u20131\u00b705), albumin (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0\u00b796 per g\/l, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b793\u20130\u00b799) and performance status (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0\u00b778 per 10\u2010point increase, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b769\u20130\u00b789). <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> did not improve outcomes in paediatric <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> compared to less intensive regimens in Malawi.<\/jats:p>","DOI":"10.1111\/bjh.13986","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T01:56:56Z","timestamp":1456451816000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Outcomes for paediatric Burkitt lymphoma treated with anthracycline\u2010based therapy in Malawi"],"prefix":"10.1111","volume":"173","author":[{"given":"Christopher C.","family":"Stanley","sequence":"first","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate D.","family":"Westmoreland","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett J.","family":"Heimlich","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader K.","family":"El\u2010Mallawany","sequence":"additional","affiliation":[{"name":"New York Medical College Valhalla New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wasswa","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idah","family":"Mtete","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercy","family":"Butia","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salama","family":"Itimu","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Chasela","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mtunda","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children's Foundation Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Chikasema","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Makwakwa","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongani","family":"Kaimila","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwards","family":"Kasonkanji","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Chimzimu","sequence":"additional","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe 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