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A planned exploratory sub\u2010study compared the two strategies for small lymphocytic (<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>) and marginal zone lymphomas (<jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>). Patients responding to rituximab weekly \u00d7 4 were randomized to <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> (single dose rituximab every 3\u00a0months until treatment failure) or <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> (rituximab weekly \u00d7 4) at the time of each progression until treatment failure. The primary endpoint was time to treatment failure (<jats:styled-content style=\"fixed-case\">TTTF<\/jats:styled-content>). Patients with <jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a057), <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a071) and unclassifiable small B\u2010cell lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) received induction rituximab. The overall response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) was 40% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 31\u201349%; <jats:styled-content style=\"fixed-case\">SLL ORR<\/jats:styled-content> 22\u00b78%; <jats:styled-content style=\"fixed-case\">MZL ORR<\/jats:styled-content> 52\u00b71%]; all 52 responders were randomized. At a median of 4\u00b73\u00a0years from randomization, treatment failure occurred in 18\/23 <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> and 15\/29 <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>. The median <jats:styled-content style=\"fixed-case\">TTTF<\/jats:styled-content> was 1\u00b74\u00a0years for <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> and 4\u00b78\u00a0years for <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012); median time to first cytotoxic therapy was 6\u00b73\u00a0years for <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> and not reached for <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70002). Survival did not differ (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b772). In low tumour burden <jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> patients responding to rituximab induction, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> significantly improved <jats:styled-content style=\"fixed-case\">TTTF<\/jats:styled-content> as compared with <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14007","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T20:00:05Z","timestamp":1457812805000},"page":"867-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Rituximab extended schedule or retreatment trial for low tumour burden non\u2010follicular indolent B\u2010cell non\u2010Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402"],"prefix":"10.1111","volume":"173","author":[{"given":"Michael E.","family":"Williams","sequence":"first","affiliation":[{"name":"University of Virginia Cancer Center Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxin","family":"Hong","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency Center for Lymphoid Cancer Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne I.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Krauss","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lode J.","family":"Swinnen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Schuster","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Aspirus Regional Cancer Center Wausau WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Sborov","sequence":"additional","affiliation":[{"name":"Fairview\u2010Southdale Hospital St. Louis Park MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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