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We analysed <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> parameters in 33 healthy controls and 148 patients with monoclonal gammopathy of undetermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>) or smouldering multiple myeloma (<jats:styled-content style=\"fixed-case\">SMM<\/jats:styled-content>) according to the 2003 <jats:styled-content style=\"fixed-case\">IMWG<\/jats:styled-content> guidelines. All individuals underwent standardized <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of the lumbar spine. Regions of interest were drawn manually on T1\u2010weighted images encompassing the bone marrow of each of the 5 lumbar vertebrae sparing the vertebral vessel. Prognostic significance for median of amplitude <jats:italic>A<\/jats:italic> (univariate: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001, hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 2\u00b742, multivariate <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2\u00b77) and exchange rate constant <jats:italic>kep<\/jats:italic> (univariate <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1\u00b792, multivariate <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b746, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1\u00b75) for time to progression of 79 patients with <jats:styled-content style=\"fixed-case\">SMM<\/jats:styled-content> was found. Patients with amplitude <jats:italic>A<\/jats:italic> above the optimal cut\u2010off point of 0\u00b789 arbitrary units had a 2\u2010year progression rate into symptomatic disease of 80%. In conclusion, <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> parameters are of prognostic significance for time to progression in patients with <jats:styled-content style=\"fixed-case\">SMM<\/jats:styled-content> but not in individuals with <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14038","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:57:46Z","timestamp":1458349066000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Increased microcirculation detected by dynamic contrast\u2010enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma"],"prefix":"10.1111","volume":"174","author":[{"given":"Jens","family":"Hillengass","sequence":"first","affiliation":[{"name":"Department 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