{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T03:34:10Z","timestamp":1758944050363},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tayside Leukaemia Research Endowment Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Genetic and epigenetic alterations contribute to the biological and clinical characteristics of myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>), but a role for socioeconomic environment remains unclear. Here, socioeconomic status (<jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>) for 283 <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> patients was estimated using the Scottish Index of Multiple Deprivation tool. Indices were assigned to quintile categorical indicators ranked from <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>1 (lowest) to <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>5 (highest). Clinicopathological features and outcomes between <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content> quintiles containing 15%, 20%, 19%, 30% and 16% of patients were compared. Prognostic scores identified lower\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> in 82% of patients, with higher\u2010risk disease in 18%. <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content> quintiles did not associate with age, gender, cytogenetics, International Prognostic scores\u00a0or, in sub\u2010analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a095), driver mutations. The odds ratio of a diagnosis of refractory anaemia was greater than other <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> sub\u2010types in <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>5 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b79, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7024). Most patients (91%) exclusively received supportive care. <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content> did not associate with leukaemic transformation or cause of death. Cox regression models confirmed male gender (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), disease\u2010risk (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) and age (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) as independent predictors of leukaemia\u2010free survival, with leukaemic transformation an additional determinant of overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b707). Thus, if access to healthcare is equitable, <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content> does not determine disease biology or survival in <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> patients receiving supportive treatment; additional studies are required to determine whether outcomes following disease\u2010modifying therapies are influenced by <jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14042","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T09:11:15Z","timestamp":1461229875000},"page":"227-234","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes"],"prefix":"10.1111","volume":"174","author":[{"given":"Francesca","family":"Mastaglio","sequence":"first","affiliation":[{"name":"Dundee Cancer Centre Ninewells Hospital &amp; Medical School University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Bedair","sequence":"additional","affiliation":[{"name":"Division of Population Health Sciences University of Dundee Dundee UK"},{"name":"Photobiology Unit Department of Dermatology Ninewells Hospital &amp; Medical School University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elli","family":"Papaemmanuil","sequence":"additional","affiliation":[{"name":"Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Groves","sequence":"additional","affiliation":[{"name":"Dundee Cancer Centre Ninewells Hospital &amp; Medical School University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Hyslop","sequence":"additional","affiliation":[{"name":"Department of Haematology Ninewells Hospital &amp; Medical School University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norene","family":"Keenan","sequence":"additional","affiliation":[{"name":"Department of Haematology Ninewells Hospital &amp; Medical School University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor J.","family":"Hothersall","sequence":"additional","affiliation":[{"name":"Division of Population Health Sciences University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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