{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:42:34Z","timestamp":1791553354066,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"We investigated whether pregnancy loss increases the risk of arterial thrombosis in young women. Women (age 18\u201350\u00a0years) with ischaemic stroke (IS<\/jats:styled-content>) or myocardial infarction (MI<\/jats:styled-content>) and at least one pregnancy were compared for pregnancy loss in a control group. Odds ratios (OR<\/jats:styled-content>) with 95% confidence intervals (CI<\/jats:styled-content>), adjusted for matching variables, cardiovascular risk factors, cardiovascular family history and the presence of antiphospholipid antibodies, were calculated for the number of pregnancy losses as well as the type of unsuccessful pregnancy (early miscarriage, late miscarriage and stillbirth). 165 IS<\/jats:styled-content> cases, 218 MI<\/jats:styled-content> cases and 743 controls were included. Women with multiple (\u22653) pregnancy loss had a doubled risk of arterial thrombosis (OR<\/jats:styled-content> 2\u00b737, 95%CI<\/jats:styled-content> 0\u00b799\u20135\u00b770) compared with women without pregnancy loss, similarly to women who experienced stillbirth (OR<\/jats:styled-content> 1\u00b768, 95%CI<\/jats:styled-content> 0\u00b779\u20133\u00b755). Both relative risks were higher for IS<\/jats:styled-content> (OR<\/jats:styled-content> 3\u00b751, 95%CI<\/jats:styled-content> 1\u00b708\u201311\u00b735 and 2\u00b706, 95%CI<\/jats:styled-content> 0\u00b781\u20135\u00b723, respectively) than for MI<\/jats:styled-content> (OR<\/jats:styled-content> 2\u00b704, 95%CI<\/jats:styled-content> 0\u00b771\u20135\u00b786 and 1\u00b704, 95%CI<\/jats:styled-content> 0\u00b739\u20132\u00b779). Adjustment for antiphospholipid antibodies did not affect the estimates. Multiple pregnancy loss and stillbirth increases the risk of IS<\/jats:styled-content> and, to a lesser extent, of MI<\/jats:styled-content>, even when other cardiovascular risk factors and antiphospholipid antibodies are accounted for.<\/jats:p>","DOI":"10.1111\/bjh.14043","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:49:34Z","timestamp":1460310574000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pregnancy loss and risk of ischaemic stroke and myocardial infarction"],"prefix":"10.1111","volume":"174","author":[{"given":"Alberto","family":"Maino","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Centre Leiden The Netherlands"},{"name":"A. Bianchi Bonomi Haemophilia and Thrombosis Centre Fondazione IRCCS Ca\u2019 Granda \u2010 Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Siegerink","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Centre Leiden The Netherlands"},{"name":"Centre for Stroke research Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Centre Leiden The Netherlands"},{"name":"Brain Centre Rudolph Magnus dept Neurology and Neurosurgery University Medical Centre Utrecht Utrecht the Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Martinelli","sequence":"additional","affiliation":[{"name":"A. Bianchi Bonomi Haemophilia and Thrombosis Centre Fondazione IRCCS Ca\u2019 Granda \u2010 Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[{"name":"A. Bianchi Bonomi Haemophilia and Thrombosis Centre Fondazione IRCCS Ca\u2019 Granda \u2010 Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Centre Leiden The Netherlands"},{"name":"Department of Thrombosis and Haemostasis Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000015028.52771.D1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09112.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.463"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000251522.18094.d4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000015345.61324.3F"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903380758"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.202226"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(99)00038-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62187-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01121.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.042"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000202107.73095.ad"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.020"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh064"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000285"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70193-5"},{"key":"e_1_2_7_19_1","first-page":"e2","article-title":"Heart disease and stroke statistics\u20132012 update: a report from the American Heart Association","volume":"125","author":"Roger V.L.","year":"2012","journal-title":"Circulation"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00714.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7386.423"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02890.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003216"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.12.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70239-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00079.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:52:04Z","timestamp":1696308724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,7]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/bjh.14043"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14043","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,7]]},"assertion":[{"value":"2015-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}