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They are represented in large part by extranodal T\/<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell lymphomas\u2010 nasal\u2010type or extra nasal\u2010type, chronic lymphoproliferative disorders of T\/<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells or chronic active <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> disease, systemic <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive lymphoproliferative disorders of childhood, hydroa vacciniforme\u2010like lymphoma, hepatosplenic T\u2010cell lymphoma and primary cutaneous gamma\/delta T\u2010cell lymphoma among others. Many T\/<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell neoplasms in this age group are derived from cells of the innate immune system, in contrast to adults where they are predominantly from the adaptive immune system. The genetic basis of T\/<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell lymphomas in children and young adolescents remains largely unknown. Anthracycline\u2010based regimens and haematopoietic stem cell transplants (allogeneic and autologous) are current treatment modalities, however it is anticipated that novel targeted therapeutic agents will be available in the near future.<\/jats:p>","DOI":"10.1111\/bjh.14044","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:58:17Z","timestamp":1458349097000},"page":"573-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mature T\u2010 and <scp>NK<\/scp>\u2010cell non\u2010Hodgkin lymphoma in children and young adolescents"],"prefix":"10.1111","volume":"173","author":[{"given":"Vinodh","family":"Pillai","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania University of Pennsylvania Philadelphia PA USA"},{"name":"Department of Pathology and Laboratory Medicine The Children's Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tallarico","sequence":"additional","affiliation":[{"name":"Section\u00a0of Hematology\u2010Oncology Department of Medicine University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Section\u00a0of Hematology\u2010Oncology Department of Medicine University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania University of Pennsylvania Philadelphia PA USA"},{"name":"Department of Pathology and Laboratory Medicine The Children's Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802455867"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182707592"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.028"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819f19bb"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23843"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000307"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12217"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.4223"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20587"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.11.003"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.6"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12352"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.029"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12452"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2013.04.006"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24462"},{"key":"e_1_2_16_19_1","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1016\/j.jaad.2013.08.033","article-title":"Primary cutaneous T\u2010cell lymphoma (mycosis fungoides and Sezary syndrome): part II. 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