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Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004382","name":"WellPoint","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Summary<\/jats:title>\n \n For diffuse large B\u2010cell lymphoma (\n DLBCL<\/jats:styled-content>\n ) patients progressing after autologous haematopoietic cell transplantation (auto\n HCT<\/jats:styled-content>\n ), allogeneic\n HCT<\/jats:styled-content>\n (allo\n HCT<\/jats:styled-content>\n ) is often considered, although limited information is available to guide patient selection. Using the Center for International Blood and Marrow Transplant Research (\n CIBMTR<\/jats:styled-content>\n ) database, we identified 503 patients who underwent allo\n HCT<\/jats:styled-content>\n after disease progression\/relapse following a prior auto\n HCT<\/jats:styled-content>\n . The 3\u2010year probabilities of non\u2010relapse mortality, progression\/relapse, progression\u2010free survival (\n PFS<\/jats:styled-content>\n ) and overall survival (\n OS<\/jats:styled-content>\n ) were 30, 38, 31 and 37% respectively. Factors associated with inferior\n PFS<\/jats:styled-content>\n on multivariate analysis included Karnofsky performance status (\n KPS<\/jats:styled-content>\n ) <80, chemoresistance, auto\n HCT<\/jats:styled-content>\n to allo\n HCT<\/jats:styled-content>\n interval <1\u2010year and myeloablative conditioning. Factors associated with worse\n OS<\/jats:styled-content>\n on multivariate analysis included\n KPS<\/jats:styled-content>\n <80, chemoresistance and myeloablative conditioning. Three adverse prognostic factors were used to construct a prognostic model for\n PFS<\/jats:styled-content>\n , including\n KPS<\/jats:styled-content>\n <80 (4 points), auto\n HCT<\/jats:styled-content>\n to allo\n HCT<\/jats:styled-content>\n interval <1\u2010year (2 points) and chemoresistant disease at allo\n HCT<\/jats:styled-content>\n (5 points). This\n CIBMTR<\/jats:styled-content>\n prognostic model classified patients into four groups: low\u2010risk (0 points), intermediate\u2010risk (2\u20105 points), high\u2010risk (6\u20109 points) or very high\u2010risk (11 points), predicting 3\u2010year\n PFS<\/jats:styled-content>\n of 40, 32, 11 and 6%, respectively, with 3\u2010year\n OS<\/jats:styled-content>\n probabilities of 43, 39, 19 and 11% respectively. In conclusion, the\n CIBMTR<\/jats:styled-content>\n prognostic model identifies a subgroup of\n DLBCL<\/jats:styled-content>\n patients experiencing long\u2010term survival with allo\n HCT<\/jats:styled-content>\n after a failed prior auto\n HCT<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/bjh.14046","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T20:59:50Z","timestamp":1458334790000},"page":"235-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Allogeneic transplantation provides durable remission in a subset of\n DLBCL<\/scp>\n patients relapsing after autologous transplantation"],"prefix":"10.1111","volume":"174","author":[{"given":"Timothy S.","family":"Fenske","sequence":"first","affiliation":[{"name":"Froedtert Memorial Lutheran Hospital Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine CIBMTR (Center for International Blood and Marrow Transplant Research) Medical College of Wisconsin Milwaukee WI USA"},{"name":"Division of Biostatistics Institute for Health and Society Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Graff","sequence":"additional","affiliation":[{"name":"Medical Oncology Hematology Associates Des Moines IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"DiGilio","sequence":"additional","affiliation":[{"name":"Department of Medicine CIBMTR (Center for International Blood and Marrow Transplant Research) Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaiser","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rammurti T.","family":"Kamble","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Center for Cell and Gene Therapy Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. 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