{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:08:46Z","timestamp":1781276926946,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The ability of positron emission tomography\u2010computerized tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) to accurately detect bone marrow involvement (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) has been suggested in Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) and diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>), but its abilities in other histologies is less established. The aim of this retrospective study was to confirm the role of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in detecting <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>, and to explore its usefulness in other subtypes. Of the 149 newly diagnosed patients, common subtypes included <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, the sensitivity and specificity of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> at diagnosis were 75% and 92%. In <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, the sensitivity and specificity of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> were 67% and 85% at diagnosis, and 73% and 89% at relapse. In <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>, the sensitivity and specificity were 100% and 74%. <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was able to detect <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in patients with negative biopsies. Most of the patients in which <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> failed to identify <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were already advanced stage by imaging. In this analysis, <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was highly accurate for detecting <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> at diagnosis in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> and highly specific in <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> at diagnosis and relapse. Results also suggested the diagnostic advantage of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> over bone marrow biopsy in detecting <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Prospective evaluation is necessary and may eliminate biopsies in future patients.<\/jats:p>","DOI":"10.1111\/bjh.14071","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T10:03:03Z","timestamp":1461232983000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["<sup>18<\/sup>F\u2010<scp>FDG PET<\/scp>\u2010<scp>CT<\/scp> and trephine biopsy assessment of bone marrow involvement in lymphoma"],"prefix":"10.1111","volume":"174","author":[{"given":"Chaitra S.","family":"Ujjani","sequence":"first","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Hill","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Nassif","sequence":"additional","affiliation":[{"name":"Department of Pathology Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Ozdemirli","sequence":"additional","affiliation":[{"name":"Department of Pathology Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cordova","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Cheson","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Medstar Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2623-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-014-0920-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008486928190"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-3-365"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.9.3340"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.5402"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31828e9504"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.4036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170512"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811193392104"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23779"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23760"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1182\/blood.V116.21.4138.4138","article-title":"The Mystery of FDG\u2010PET Avidity In Follicular Lymphoma. 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