{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:59:33Z","timestamp":1790917173782,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Summary<\/jats:title>\n \n It is suspected that primary central nervous system lymphoma (\n PCNSL<\/jats:styled-content>\n ) rates are increasing among immunocompetent people. We estimated\n PCNSL<\/jats:styled-content>\n trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency virus (\n HIV<\/jats:styled-content>\n )\u2010infected persons and transplant recipients.\n PCNSL<\/jats:styled-content>\n data were derived from 10 Surveillance, Epidemiology and End Results (\n SEER<\/jats:styled-content>\n ) cancer registries (1992\u20132011).\n HIV<\/jats:styled-content>\n \u2010infected cases had reported\n HIV<\/jats:styled-content>\n infection or death due to\n HIV<\/jats:styled-content>\n . Transplant recipient cases were estimated from the Transplant Cancer Match Study. We estimated\n PCNSL<\/jats:styled-content>\n trends overall and among immunocompetent individuals, and survival by\n HIV<\/jats:styled-content>\n status. A total of 4158\n PCNSL<\/jats:styled-content>\n s were diagnosed (36%\n HIV<\/jats:styled-content>\n \u2010infected; 0\u00b79% transplant recipients).\n HIV<\/jats:styled-content>\n prevalence in\n PCNSL<\/jats:styled-content>\n cases declined from 64\u00b71% (1992\u20131996) to 12\u00b77% (2007\u20132011), while the prevalence of transplant recipients remained low. General population\n PCNSL<\/jats:styled-content>\n rates were strongly influenced by immunosuppressed cases, particularly in 20\u201339 year\u2010old men. Among immunocompetent people,\n PCNSL<\/jats:styled-content>\n rates in men and women aged 65+ years increased significantly (1\u00b77% and 1\u00b76%\/year), but remained stable in other age groups. Five\u2010year survival was poor, particularly among\n HIV<\/jats:styled-content>\n \u2010infected cases (9\u00b70%). Among\n HIV<\/jats:styled-content>\n \u2010uninfected cases, 5\u2010year survival increased from 19\u00b71% (1992\u20131994) to 30\u00b71% (2004\u20132006). In summary,\n PCNSL<\/jats:styled-content>\n rates have increased among immunocompetent elderly adults, but not in younger individuals. Survival remains poor for both\n HIV<\/jats:styled-content>\n \u2010infected and\n HIV<\/jats:styled-content>\n \u2010uninfected\n PCNSL<\/jats:styled-content>\n patients.\n <\/jats:p>","DOI":"10.1111\/bjh.14073","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T01:46:45Z","timestamp":1459129605000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":253,"title":["Trends in primary central nervous system lymphoma incidence and survival in the U.S."],"prefix":"10.1111","volume":"174","author":[{"given":"Meredith S.","family":"Shiels","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Besson","sequence":"additional","affiliation":[{"name":"Bic\u00eatre University Hospital Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Cancer Prevention Institute of California Fremont CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"Morton","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Texas Department of State Health Services Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Pawlish","sequence":"additional","affiliation":[{"name":"New Jersey Department of Health Trenton NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Yanik","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Suneja","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Engels","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328332533b"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0252-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.130"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","author":"Centers for Disease Control and Prevention","year":"1992","journal-title":"MMWR \u2010 Recommendations and Reports"},{"key":"e_1_2_9_6_1","unstructured":"Centers for Disease Control and Prevention. 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