{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:01:59Z","timestamp":1759341719919},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Response to treatment in patients with a plasma cell disorder is typically measured by evaluating the bone marrow and myeloma markers, including monoclonal protein spike and immunofixation (<jats:styled-content style=\"fixed-case\">IFE<\/jats:styled-content>) in blood and urine, and serum free light chains (<jats:styled-content style=\"fixed-case\">sFLC<\/jats:styled-content>s). Stringent complete response criteria for Multiple Myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) patients require a normal <jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content> ratio and absence of clonal cells in bone marrow by immunohistochemistry or immunofluorescence. We performed a retrospective chart review to further evaluate these criteria. A total of 142 patient charts were analysed. Of these, 17 patients were found to have an abnormal <jats:styled-content style=\"fixed-case\">sFLC<\/jats:styled-content> ratio, but no other evidence of disease, including normal flow cytometry and normal fluorescence <jats:italic>in\u00a0situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) analysis on highly selected plasma cells. In all patients, the abnormal <jats:styled-content style=\"fixed-case\">sFLC<\/jats:styled-content> ratio was caused by abnormalities in the serum kappa light chains. These results suggest that current definitions may need to be revised to take aberrancies related to abnormal immune recovery into account.<\/jats:p>","DOI":"10.1111\/bjh.14081","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:12:57Z","timestamp":1463098377000},"page":"536-540","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potential pitfalls of serum free light chain analysis to assess treatment response for multiple myeloma"],"prefix":"10.1111","volume":"174","author":[{"given":"Kamal Kant Singh","family":"Abbi","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Silverman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Tricot","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Dozeman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyan","family":"Nadiminti","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Krasowski","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido J.","family":"Tricot","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Blood &amp; Marrow Transplantation Department of Internal Medicine University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1182\/blood.V122.21.1895.1895","article-title":"The value of serum free light chain monitoring compared to urinary Bence\u2010Jones measurement in light chain only myeloma","volume":"122","author":"Boyle E.M.","year":"2013","journal-title":"Blood"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.048017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/clinchem\/47.4.673","article-title":"Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine","volume":"47","author":"Bradwell A.R.","year":"2001","journal-title":"Clinical Chemistry."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-542662"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"974a","DOI":"10.1182\/blood.V106.11.3490.3490","article-title":"Serum free\u2010lite chain (sFLC) assay in multiple myeloma (MM): clinical correlates and prognostic implications in newly diagnosed MM patients treated with total therapy 2 or 3 (TT2\/3)","volume":"106","author":"Cavallo F.","year":"2005","journal-title":"Blood"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.6.1625"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-108357"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.307"},{"key":"e_1_2_9_10_1","first-page":"113","article-title":"Significance of abnormal protein bands in patients with multiple myeloma following autologous stem cell transplantation","volume":"30","author":"Hall S.L.","year":"2009","journal-title":"The Clinical Biochemist. 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