{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:30:42Z","timestamp":1789014642413,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014181","name":"Junta de Extremadura","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014181","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundaci\u00f3n Espa\u00f1ola de Hematolog\u00eda (FEHH)"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Cancer","award":["RD12\/0036\/0014"],"award-info":[{"award-number":["RD12\/0036\/0014"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Summary<\/jats:title>The combination of fludarabine, cytarabine, idarubicin, and granulocyte colony\u2010stimulating factor (FLAG<\/jats:styled-content>\u2010Ida) is widely used in relapsed\/refractory acute myeloid leukaemia (AML<\/jats:styled-content>). We retrospectively analysed the results of 259 adult AML<\/jats:styled-content> patients treated as first salvage with FLAG<\/jats:styled-content>\u2010Ida or FLAG<\/jats:styled-content>\u2010Ida plus Gentuzumab\u2010Ozogamicin (FLAGO<\/jats:styled-content>\u2010Ida) of the Programa Espa\u00f1ol de Tratamientos en Hematolog\u00eda (PETHEMA<\/jats:styled-content>) database, developing a prognostic score system of survival in this setting (SALFLAGE<\/jats:styled-content> score). Overall, 221 patients received FLAG<\/jats:styled-content>\u2010Ida and 38 FLAGO<\/jats:styled-content>\u2010Ida; 92 were older than 60\u00a0years. The complete remission (CR<\/jats:styled-content>)\/CR<\/jats:styled-content> with incomplete blood count recovery (CR<\/jats:styled-content>i) rate was 51%, with 9% of induction deaths. Three covariates were associated with lower CR<\/jats:styled-content>\/CR<\/jats:styled-content>i: high\u2010risk cytogenetics and t<\/jats:italic>(8;21) at diagnosis, no previous allogeneic stem cell transplantation (allo\u2010SCT<\/jats:styled-content>) and relapse\u2010free interval <1\u00a0year. Allo\u2010SCT<\/jats:styled-content> was performed in second CR<\/jats:styled-content> in 60 patients (23%). The median overall survival (OS<\/jats:styled-content>) of the entire cohort was 0\u00b77\u00a0years, with 22% OS<\/jats:styled-content> at 5\u2010years. Four independent variables were used to construct the score: cytogenetics, FLT<\/jats:styled-content>3<\/jats:italic>\u2010internal tandem duplication, length of relapse\u2010free interval and previous allo\u2010SCT<\/jats:styled-content>. Using this stratification system, three groups were defined: favourable (26% of patients), intermediate (29%) and poor\u2010risk (45%), with an expected 5\u2010year OS<\/jats:styled-content> of 52%, 26% and 7%, respectively. The SALFLAGE<\/jats:styled-content> score discriminated a subset of patients with an acceptable long\u2010term outcome using FLAG<\/jats:styled-content>\u2010Ida\/FLAGO<\/jats:styled-content>\u2010Ida regimen. The results of this retrospective analysis should be validated in independent external cohorts.<\/jats:p>","DOI":"10.1111\/bjh.14107","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T14:37:26Z","timestamp":1461767846000},"page":"700-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A prognostic model for survival after salvage treatment with FLAG<\/scp>\u2010Ida +\/\u2212 gemtuzumab\u2010ozogamicine in adult patients with refractory\/relapsed acute myeloid leukaemia"],"prefix":"10.1111","volume":"174","author":[{"given":"Juan M.","family":"Bergua","sequence":"first","affiliation":[{"name":"Department of Haematology Hospital San Pedro de Alc\u00e1ntara C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital La Fe Valencia 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