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The disease is mostly incurable and characterized by a continuous pattern of relapse. Major changes have recently been implemented in the management of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>, but continuous relapses still mark this disease as a challenge for clinicians. We previously reported the efficacy of GemOx\u2010R (Gemcitabine, Oxaliplatin and Rituximab) in patients with refractory and relapsing <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>. We present results for a larger series with longer follow\u2010up and including high\u2010risk frontline patients, showing an overall response rate of 83%. The efficacy of each component of GemOx\u2010R was evaluated in a panel of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> cell lines. Also, patient\u2010derived primary cells were used in <jats:italic>ex\u00a0vivo<\/jats:italic> experiments. The results show that oxaliplatin has a profound effect on cellular viability and is the most effective drug within this regimen. We further present synergistic efficacy of oxaliplatin combined with cytarabine in <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> cells. Interestingly, this synergistic effect was not seen when cisplatin and cytarabine were combined, indicating that among the platinum\u2010derived agents oxaliplatin may be the preferred approach. Taken together our findings suggest that oxaliplatin alone or combined with cytarabine could constitute an alternative backbone for <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> regimens.<\/jats:p>","DOI":"10.1111\/bjh.14141","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T09:02:13Z","timestamp":1464166933000},"page":"899-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of the GemOx\u2010R regimen leads to the identification of Oxaliplatin as a highly effective drug against Mantle Cell Lymphoma"],"prefix":"10.1111","volume":"174","author":[{"given":"Ant\u00f2nia","family":"Obrador\u2010Hevia","sequence":"first","affiliation":[{"name":"Cancer Cell Biology Group Institut Universitari d'Investigaci\u00f3 en Ci\u00e8ncies de La Salut (IUNICS) Palma Illes Balears Spain"},{"name":"Departament de Biologia Fonamental Universitat de les Illes 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