{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:27Z","timestamp":1790740047006,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["C\u201025461442"],"award-info":[{"award-number":["C\u201025461442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>This study analysed incidence, patient outcome, immunophenotype and prognostic factors of histological transformation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) from extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma) to diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) in 467 patients (median age, 61\u00a0years). The primary sites of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma were the stomach (43%), ocular adnexa (25%), lung (8%), systemic (8%) and other tissues (16%). <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> occurred in 8% of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas. Risk of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> by 15\u00a0years was 5%: 4% in limited\u2010stage diseases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0385) and 16% in advanced\u2010stage diseases (<jats:italic>n<\/jats:italic>\u00a0=\u00a056) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b702). The median time to <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was 48\u00a0months (range, 4\u2013139). Five\u2010year progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) rates after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> were 80% and 94%, respectively. Immunohistochemical results of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> were as follows: germinal centre B\u2010cell (<jats:styled-content style=\"fixed-case\">GCB<\/jats:styled-content>)\/non\u2010<jats:styled-content style=\"fixed-case\">GCB<\/jats:styled-content>, 37%\/63%; <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10, 9%; <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>6, 59%; <jats:styled-content style=\"fixed-case\">MUM<\/jats:styled-content>1, 38%; <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>, 42%; <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2, 35%; Ki67\u00a0\u2265\u00a090%, 23%; and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5, 3%. The majority (75%, 9\/12) of <jats:styled-content style=\"fixed-case\">GCB<\/jats:styled-content>\u2010type <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>s exhibited <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10<jats:sup>\u2212<\/jats:sup>, <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>6<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">MUM<\/jats:styled-content>1<jats:sup>\u2212<\/jats:sup> immunophenotypes; the remainder had <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10<jats:sup>+<\/jats:sup> immunophenotypes. Multivariate analysis revealed that only advanced stage at <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was a significant adverse factor for <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7037). Thus, overall risk of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was low and prognosis after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was favourable; however, in advanced\u2010stage cases, risk of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was relatively high and prognosis was unfavourable.<\/jats:p>","DOI":"10.1111\/bjh.14153","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T05:28:48Z","timestamp":1469597328000},"page":"923-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Clinicopathological features of histological transformation from extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue to diffuse large B\u2010cell lymphoma: an analysis of 467 patients"],"prefix":"10.1111","volume":"174","author":[{"given":"Akiko Miyagi","family":"Maeshima","sequence":"first","affiliation":[{"name":"Department of Pathology National Cancer Centre Hospital 5\u20101\u20101 Tsukiji Chuo\u2010ku Tokyo 104\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Centre Hospital 5\u20101\u20101 Tsukiji Chuo\u2010ku Tokyo 104\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Centre Hospital 5\u20101\u20101 Tsukiji Chuo\u2010ku Tokyo 104\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Centre Hospital 5\u20101\u20101 Tsukiji Chuo\u2010ku Tokyo 104\u20100045 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