{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:36:58Z","timestamp":1789940218689,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Myelofibrosis (MF<\/jats:styled-content>) is a rare haematopoietic disorder, commonly diagnosed in the 6th decade: less than 20% are diagnosed before the age of 50\u00a0years. In this retrospective study we included all patients given a diagnosis of World Health Organization\u2010defined primary or secondary MF<\/jats:styled-content> when aged \u226450\u00a0years. Forty\u2010three patients with a median age of 43\u00a0years were included. Median follow up was 44\u00a0months. Twenty\u2010two (51%) harboured the JAK<\/jats:styled-content>2<\/jats:italic> V617F mutation, 18\/43 (42%) CALR<\/jats:styled-content><\/jats:italic>, 0\/43 (0%) MPL<\/jats:styled-content><\/jats:italic> mutations and 3\/43 (7%) were \u2018Triple Negative\u2019 (TN<\/jats:styled-content>). At the time of diagnosis, no significant differences existed in haematological and clinical phenotypes between JAK<\/jats:styled-content>2, CALR<\/jats:styled-content><\/jats:italic> and TN<\/jats:styled-content> patients. The frequency of splenomegaly was greater (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7047) in the JAK<\/jats:styled-content><\/jats:italic>2\u2010mutated group compared to CALR<\/jats:styled-content><\/jats:italic>\u2010mutated patients. In the whole cohort, the 5\u2010year probability of developing anaemia, thrombocytopenia and marked leucocytosis was 24%, 10% and 13% respectively. Finally, the cumulative incidence of thrombotic events and progression to acute myeloid leukaemia was 1% and 0\u00b75% patient\u2010year respectively. No death was reported during the follow\u2010up. These findings suggest that MF<\/jats:styled-content> in younger patients may have a more indolent course when compared to older patients.<\/jats:p>","DOI":"10.1111\/bjh.14173","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T06:13:22Z","timestamp":1465798402000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Disease characteristics and outcomes in younger adults with primary and secondary myelofibrosis"],"prefix":"10.1111","volume":"175","author":[{"given":"Yan","family":"Beauverd","sequence":"first","affiliation":[{"name":"Department of Haematology Guy's and St Thomas\u2019 NHS Foundation Trust London UK"},{"name":"Department of Haematology Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Alimam","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and 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