{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:42Z","timestamp":1790704122237,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004869","name":"Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Deficiency of antithrombin (\n                    <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                    ), protein C (\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    ) or protein S (\n                    <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\n                    ) constitutes a major risk factor for venous thromboembolism (\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    ). Individuals at high risk for recurrence who benefit from screening need to be identified. The primary study objective was to determine the individual recurrence risk among children with a first non\u2010central\u2010venous\u2010catheter\u2010associated\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    with respect to their thrombophilia status and to evaluate if the clinical presentation at first\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    onset differs between children with\n                    <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\n                    deficiency versus no thrombophilia. We calculated the absolute risk of\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    recurrence and event\u2010free\u2010survival adjusted for thrombophilia, age, sex and positive family\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    history in 161 consecutively enrolled paediatric\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    patients. The presence of a deficiency relative to no thrombophilia was evaluated as a potential predictor of recurrence. Predictors for recurrence were\n                    <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                    deficiency (hazard ratio\/95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 6\u00b75\/2\u00b746\u201317\u00b72) and female gender (2\u00b76\/1\u00b71\u20136\u00b735). The annual recurrence rates (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    s) were 5\u00b74% (2\u00b76\u201310) in\n                    <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                    \u2010deficient children, 1\u00b73% (0\u00b73\u20133\u00b78) in patients with\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    deficiency, 0\u00b77% (0\u00b708\u20132\u00b74) in the\n                    <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\n                    \u2010deficient cohort and 0\u00b79% (0\u00b74\u20131\u00b78) in patients with no thrombophilia. Positive family\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    history or combined thrombophilias did not predict recurrence. Given the overall annual incidence rate of recurrence of 1\u00b75% we suggest screening for\n                    <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                    deficiency in children with\n                    <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/bjh.14192","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T15:03:58Z","timestamp":1466694238000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of high\u2010risk thrombophilia status on recurrence among children with a first non\u2010central\u2010venous\u2010catheter\u2010associated VTE: an observational multicentre cohort study"],"prefix":"10.1111","volume":"175","author":[{"given":"Verena","family":"Limperger","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry University Hospital Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[{"name":"Thrombosis Unit, National Haemophilia Centre Tel Hashomer and the Sackler Medical School Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"All Children's Hospital Johns Hopkins Medicine and All Children's Research Institute St. Petersburg FL USA"},{"name":"Division of Hematology, Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemostaseology Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\/Oncology Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Junker","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry University Hospital Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich C.","family":"Klostermeier","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry University Hospital Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Knoefler","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemostaseology Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kurnik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Children Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kr\u00fcmpel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\/Oncology University Children Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Mesters","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Haematology &amp; Oncology Univ. 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