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Nevertheless, patterns of inheritance and the importance of genetic versus environmental risk factors in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> aetiology remain unclear. We pooled data from eleven case\u2010control studies from the International Multiple Myeloma Consortium to characterize the association of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> risk with having a first\u2010degree relative with a history of a lympho\u2010haematapoietic cancer. Unconditional logistic regression models, adjusted for study, sex, age and education level, were used to estimate associations between <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> risk and having a first\u2010degree relative with a history of non\u2010Hodgkin lymphoma, Hodgkin lymphoma, leukaemia or <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. Sex, African American race\/ethnicity and age were explored as effect modifiers. A total of 2843 cases and 11\u00a0470 controls were included. MM risk was elevated in association with having a first\u2010degree relative with any lympho\u2010haematapoietic cancer (Odds Ratio (OR)\u00a0=\u00a01\u00b729, 95% Confidence Interval (CI): 1\u00b708\u20131\u00b755). The association was particularly strong for having a first\u2010degree relative with MM (OR\u00a0=\u00a01\u00b790, 95% CI: 1\u00b726\u20132\u00b787), especially among men (OR\u00a0=\u00a04\u00b713, 95% CI: 2\u00b717\u20137\u00b785) and African Americans (OR\u00a0=\u00a05\u00b752, 95% CI: 1\u00b787\u201316\u00b727).These results support the hypothesis that genetic inheritance plays a role in MM aetiology. Future studies are warranted to characterize interactions of genetic markers with environmental exposures.<\/jats:p>","DOI":"10.1111\/bjh.14199","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T19:03:29Z","timestamp":1466708609000},"page":"87-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium"],"prefix":"10.1111","volume":"175","author":[{"given":"Leah H.","family":"Schinasi","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health Drexel University Dornsife School of Public Health Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Cancer Center School of 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(EPICEA) Villejuif France"},{"name":"Paris\u2010Descartes University UMRS\u20101153, Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Centre (CRESS) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J.","family":"Tricot","sequence":"additional","affiliation":[{"name":"Internal Medicine University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djordje","family":"Atanackovic","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies School of Medicine University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Public Health, Clinical and Molecular Medicine Occupational Health Section University of Cagliari Cagliari 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