{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:24:35Z","timestamp":1783038275658,"version":"3.54.6"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Actinium Pharmaceuticals, Inc."},{"name":"Bioline and Epizyme"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Repeated therapy of hairy cell leukaemia (<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>) with treatments that have potential long\u2010term toxicities has raised concerns regarding increased risk for younger patients. We compared clinical outcomes and disease complications in 63 patients with <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> aged \u226440\u00a0years at diagnosis with 268 patients &gt;40\u00a0years treated at Memorial Sloan Kettering Cancer Center. The rate of complete remission following initial therapy was 87% and 83% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b771) and estimated 10\u2010year overall survival was 100% and 82% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b725) in younger and older patients, respectively. Younger patients required therapy earlier and had a significantly shorter time between first and second therapy (median: 63\u00a0months vs. 145\u00a0months) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008). Younger patients required significantly more lines of therapy during follow\u2010up. The 10\u2010year cumulative incidence of secondary malignancies in young and old patients was 0\u00b7205 and 0\u00b7287, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b722). The incidence of secondary cancers in patients aged &gt;40\u00a0years at diagnosis increased with the number of treatments for <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018). These results highlight that young patients with <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> have shorter responses to treatment and require more lines of therapy to maintain disease control, while attaining similar long\u2010term survival. This has implications in the design of future clinical trials given our findings that secondary malignancies increase with more chemotherapy exposure.<\/jats:p>","DOI":"10.1111\/bjh.14207","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T14:24:24Z","timestamp":1467123864000},"page":"402-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia"],"prefix":"10.1111","volume":"175","author":[{"given":"Bartlomiej M.","family":"Getta","sequence":"first","affiliation":[{"name":"Leukemia Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin M.","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae H.","family":"Park","sequence":"additional","affiliation":[{"name":"Leukemia Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Leukemia Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Saven","sequence":"additional","affiliation":[{"name":"Scripps Clinic La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanti","family":"Rai","sequence":"additional","affiliation":[{"name":"North Shore LIJ New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Tallman","sequence":"additional","affiliation":[{"name":"Leukemia Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-201731"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-643361"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07668.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.093"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.1803"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004193221605"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351502"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508754"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.6.1918"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105358"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506583"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2828"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13528"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:29:26Z","timestamp":1696325366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,28]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/bjh.14207"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14207","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,28]]},"assertion":[{"value":"2016-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}