{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:38:02Z","timestamp":1766504282430},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nodal marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">NMZL<\/jats:styled-content>) is a rare non\u2010Hodgkin lymphoma that arises from mature B\u2010cells. We delineate outcomes, prognostic factors and treatment trends among a large cohort of patients with<jats:styled-content style=\"fixed-case\">NMZL<\/jats:styled-content>in the rituximab era. We identified 56 such patients treated at our institutions. The majority presented with advanced stage disease (78\u00b76%). Over a median follow\u2010up of 38\u00b72\u00a0months, median progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) was 42\u00b74\u00a0months and median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was not reached. Kaplan\u2013Meier estimates of<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>at 120\u00a0months after diagnosis was 71\u00b79%. High\u2010risk follicular lymphoma international prognostic index (<jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content>) was associated with inferior<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. Age &gt;60\u00a0years and elevated serum lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>) were associated with inferior<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Transformation to diffuse large B\u2010cell lymphoma occurred in 7 patients, 6 of who presented with advanced disease.<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>was comparable to our previously reported extranodal<jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>cohort.<jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content>score predicted for inferior<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>when both cohorts were analysed together (<jats:italic>n<\/jats:italic>\u00a0=\u00a0267). In summary, outcomes in<jats:styled-content style=\"fixed-case\">NMZL<\/jats:styled-content>are favourable with a large majority of patients surviving at 120\u00a0months. High risk<jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content>, age &gt;60\u00a0years, and elevated serum<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>were associated with inferior outcomes.<\/jats:p>","DOI":"10.1111\/bjh.14228","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T10:56:41Z","timestamp":1469185001000},"page":"275-280","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dual institution experience of nodal marginal zone lymphoma reveals excellent long\u2010term outcomes in the rituximab era"],"prefix":"10.1111","volume":"175","author":[{"given":"Adam G.","family":"Starr","sequence":"first","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo F.","family":"Caimi","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PingFu","family":"Fu","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira R.","family":"Massoud","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Meyerson","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Case Comprehensive Cancer Center Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Mansur","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheen","family":"Cherian","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Case Comprehensive Cancer Center Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda W.","family":"Cooper","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center\/Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos J. 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