{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:56:08Z","timestamp":1789012568323,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007363","name":"Fondazione Citt\u00e0 della Speranza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006694","name":"Associazione Italiana Contro le Leucemie - Linfomi e Mieloma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) and Diffuse Large B\u2010Cell Lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) account for most cases of non\u2010Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) in childhood. We report the clinical characteristics, outcome and prognostic factors in children with<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>treated according to the Associazione Italiana Ematologia Oncologia Pediatrica (<jats:styled-content style=\"fixed-case\">AIEOP<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">LNH<\/jats:styled-content>\u201097 protocol. Patients aged up to 18\u00a0years that were newly diagnosed with<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>were included in the study. Therapy consisted of pre\u2010phase followed by 2\u20136 high\u2010dose chemotherapy courses tailored according to lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>) value and disease stage. A total of 442 patients (379<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>, 63<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) were enrolled between 1997 and 2014, of whom 18 failed to achieve remission, 6 experienced treatment\u2010related death, 2 developed second malignancy and 20 relapsed. At a median follow\u2010up time of 5\u00a0years, overall survival was 93% (\u00b11%) and event\u2010free survival was 90% (\u00b11%).<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>value above the median value had an independently negative prognostic value (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). However, in the subgroup of 128 patients in which minimal disseminated disease (<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>) was analysed,<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>\u2010positivity became the only unfavourable prognostic factor for progression\u2010free survival. Tailored chemotherapy could be extremely effective with limited toxicity. Identification of<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>as a hallmark of a higher risk of treatment failure may provide a target population for treatment intensification by anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20.<\/jats:p>","DOI":"10.1111\/bjh.14240","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T13:02:48Z","timestamp":1467982968000},"page":"467-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B\u2010Cell Lymphoma treated with the<scp>AIEOP LNH<\/scp>\u201097 protocol"],"prefix":"10.1111","volume":"175","author":[{"given":"Marta","family":"Pillon","sequence":"first","affiliation":[{"name":"Clinic of Paediatric Haemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Mussolin","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Haemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"},{"name":"Institute of Paediatric Research \u2013 Fondazione Citt\u00e0 della Speranza Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Carraro","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Haemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentino","family":"Conter","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Ospedale San Gerardo University of Milano\u2010Bicocca Fondazione MBBM Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Aric\u00f2","sequence":"additional","affiliation":[{"name":"Medical Department Paediatric Unit Azienda Sanitaria Provinciale Ragusa Ragusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Vinti","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology IRCCS Ospedale Bambino Ges\u00f9 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Garaventa","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology IRCCS I. 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Gaslini Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Piglione","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology Regina Margherita Children's Hospital Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Buffardi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology Santobono\u2010Pausilipon Children's Hospital Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Sala","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Ospedale San Gerardo University of Milano\u2010Bicocca Fondazione MBBM Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lo Nigro","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology Azienda Policlinico\u2010OVE Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Mura","sequence":"additional","affiliation":[{"name":"Paediatric Haematology\u2010Oncology Ospedale Pediatrico Microcitemico Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Tondo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\u2010Oncology Azienda Ospedaliero\u2010Universitaria Meyer Children Hospital Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorina","family":"Casale","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology University of Napoli Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Farruggia","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology ARNAS Ospedali Civico, G Di Cristina Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pierani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Paediatric Haematology Oncology Azienda Ospedaliera Universitaria Integrata Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele S. 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