{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:14:14Z","timestamp":1792080854286,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The incidence and prognostic impact of nephropathy related to Waldenstr\u00f6m macroglobulinaemia (\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    ) is currently unknown. We performed a retrospective study to assess biopsy\u2010confirmed\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    \u2010related nephropathy in a cohort of 1391\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    patients seen at a single academic institution. A total of 44 cases were identified, the estimated cumulative incidence was 5\u00b71% at 15\u00a0years. There was a wide variation in kidney pathology, some directly related to the\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    : amyloidosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011, 25%), monoclonal\u2010IgM deposition disease\/cryoglobulinaemia (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010, 23%), lymphoplasmacytic lymphoma infiltration (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08, 18%), light\u2010chain deposition disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04, 9%) and light\u2010chain cast nephropathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04, 9%), and some probably related to the\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    : thrombotic microangiopathy (\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    ) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03, 7%), minimal change disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02, 5%), membranous nephropathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01, 2%) and crystal\u2010storing tubulopathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01, 2%). The median overall survival in patients with biopsy\u2010confirmed\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    \u2010related nephropathy was 11\u00b75\u00a0years, shorter than for the rest of the cohort (16\u00a0years,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b703). Survival was better in patients with stable or improved renal function after treatment (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b705). Based on these findings, monitoring for renal disease in\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    patients should be considered and a kidney biopsy pursued in those presenting with otherwise unexplained renal failure and\/or nephrotic syndrome.\n                  <\/jats:p>","DOI":"10.1111\/bjh.14279","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T17:14:44Z","timestamp":1479316484000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Renal disease related to Waldenstr\u00f6m macroglobulinaemia: incidence, pathology and clinical outcomes"],"prefix":"10.1111","volume":"175","author":[{"given":"Josephine M.","family":"Vos","sequence":"first","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"},{"name":"Department of Internal Medicine\/Haematology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Gustine","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut G.","family":"Rennke","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Hunter","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Manning","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni E.","family":"Dubeau","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Meid","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Minnema","sequence":"additional","affiliation":[{"name":"Department of Haematology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Jose","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Haematology UMC Utrecht Cancer Centre Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Treon","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-7532","authenticated-orcid":false,"given":"Jorge J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute Boston MA USA"},{"name":"Harvard Medical School Boston MA 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