{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:42:33Z","timestamp":1791052953092,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The reported higher risk of maternal and fetal complications in women with myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>) poses challenge during pregnancy. A national prospective study of maternal and fetal outcomes of pregnant women with a diagnosis of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> was undertaken via the United Kingdom Obstetric Surveillance System between January 2010 and December 2012. Fifty\u2010eight women with a diagnosis of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> were identified; 47 (81%) essential thrombocythaemia, five (9%) polycythaemia vera, five (9%) myelofibrosis and one (2%) <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\u2010unclassified. There were 58 live births. The incidence of miscarriage was 1\u00b77\/100 (95% confidence interval [CI]: 0\u00b704\u20139\u00b724) and the perinatal mortality rate was 17\/1000 (95% CI:\u00a00\u00b744\u201392\u00b736) live and stillbirths. Incidence of maternal complications was 9% (5\/57) pre\u2010eclampsia, 9% (5\/57) post\u2010partum haemorrhage and 3\u00b75% (2\/57) post\u2010partum haematoma. There were no maternal deaths or thrombotic events. Delivery was induced in 45% (24\/53) of women and the Caesarean section rate was 45% (24\/53). The majority (85%, 45\/53) delivered at term (&gt;37\u00a0weeks gestation). Twenty\u2010two percent (12\/54) of neonates were below the 10% centile for growth and 13% (7\/54) required admission to a neonatal care\u2010unit; there were no neonatal deaths. The findings of this large, UK prospective study suggests women with MPN appear to have successful pregnancies with better outcomes than would be anticipated from the literature.<\/jats:p>","DOI":"10.1111\/bjh.14289","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T16:29:54Z","timestamp":1473438594000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Pregnancy outcomes in myeloproliferative neoplasms: <scp>UK<\/scp> prospective cohort study"],"prefix":"10.1111","volume":"175","author":[{"given":"Samah","family":"Alimam","sequence":"first","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bewley","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Knight","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Seed","sequence":"additional","affiliation":[{"name":"Women's Health Academic Centre King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Guy's and St. Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"key":"e_1_2_7_3_1","first-page":"215","article-title":"Practice guidelines for the therapy of essential thrombocythemia. 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