{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:07:02Z","timestamp":1787602022349,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Plasmacytoma is characterized by a local accumulation of monoclonal plasma cells without criteria for multiple myeloma (MM<\/jats:styled-content>). The current treatment regimen is local radiotherapy. However, more than 50% of patients develop MM<\/jats:styled-content> within 2\u00a0years after treatment. A population\u2010based registry was consulted for the diagnosis of solitary plasmacytoma between 1988 and 2011. Progression to MM<\/jats:styled-content> and prognostic features for progression to MM<\/jats:styled-content> were scored, including hypoxia inducible factors (HIF<\/jats:styled-content>), vascular endothelial growth factor (VEGF<\/jats:styled-content>, also termed VEGFA<\/jats:styled-content>) and micro\u2010vessel density (MVD<\/jats:styled-content>) expression in biopsy material. A total of 76 patients were included, 34% having extramedullary plasmacytoma (EMP<\/jats:styled-content>) while 66% had a solitary plasmacytoma of the bone (SBP<\/jats:styled-content>). Median follow\u2010up was 89\u00a0months, (7\u2013293\u00a0months). In Seventy per cent of SBP<\/jats:styled-content> patients developed MM<\/jats:styled-content> with a median time to progression of 19\u00a0months (5\u2013293). Three patients (12%) with EMP<\/jats:styled-content> developed MM<\/jats:styled-content>. High expression of VEGF<\/jats:styled-content> and HIF<\/jats:styled-content>\u20102\u03b1 (also termed EPAS<\/jats:styled-content>1) was demonstrated in conjunction with an increased MVD<\/jats:styled-content> in 66% of the patients. No association could be shown between angiogenesis parameters and progression to MM<\/jats:styled-content>. In conclusion, this population\u2010based study demonstrates that SBP<\/jats:styled-content> patients have a higher risk of developing MM<\/jats:styled-content> following local radiotherapy, indicating that this group might benefit from added systemic chemotherapy.<\/jats:p>","DOI":"10.1111\/bjh.14291","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T03:47:23Z","timestamp":1473306443000},"page":"661-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Progression of a solitary plasmacytoma to multiple myeloma. A population\u2010based registry of the northern Netherlands"],"prefix":"10.1111","volume":"175","author":[{"given":"Esther G. 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