{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:29:42Z","timestamp":1788236982998,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Involvement of the internal female reproductive organs by diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) is uncommon, and there are sparse data describing the outcomes of such cases. In total, 678 female patients with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> staged with positron emission tomography\/computed tomography and treated with rituximab\u2010containing chemotherapy were identified from databases in Denmark, Great Britain, Australia, and Canada. Overall, 27\/678 (4%) had internal reproductive organ involvement: uterus (<jats:italic>n<\/jats:italic>\u00a0=\u00a014), ovaries (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) or both (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). In multivariate analysis, women with uterine <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> experienced inferior progression\u2010free survival and overall survival compared to those without reproductive organ involvement, whereas ovarian <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> was not predictive of outcome. Secondary central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) involvement (<jats:styled-content style=\"fixed-case\">SCNS<\/jats:styled-content>) occurred in 7\/17 (41%) women with uterine <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (two patients with concomitant ovarian <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) and 0\/10 women with ovarian <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> without concomitant uterine involvement. In multivariate analysis adjusted for other risk factors for <jats:styled-content style=\"fixed-case\">SCNS<\/jats:styled-content>, uterine involvement by <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> remained strongly associated with <jats:styled-content style=\"fixed-case\">SCNS<\/jats:styled-content> (Hazard ratio 14\u00b713, 95% confidence interval 5\u00b709\u201339\u00b725, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Because involvement of the uterus by <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> appears to be associated with a high risk of <jats:styled-content style=\"fixed-case\">SCNS<\/jats:styled-content>, those patients should be considered for <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> staging and prophylaxis. However, more studies are needed to determine whether the increased risk of secondary <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement also applies to women with localized reproductive organ <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14325","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T11:04:58Z","timestamp":1475147098000},"page":"876-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Uterine, but not ovarian, female reproductive organ involvement at presentation by diffuse large B\u2010cell lymphoma is associated with poor outcomes and a high frequency of secondary <scp>CNS<\/scp> involvement"],"prefix":"10.1111","volume":"175","author":[{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"first","affiliation":[{"name":"Department of Haematology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-1565","authenticated-orcid":false,"given":"Chan Y.","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Haematology Sir Charles Gairdner Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabegh George","family":"Mikhaeel","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Guy's and St Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology British Columbia Cancer Agency Centre for Lymphoid Cancer and the University of British Columbia Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H.","family":"Sehn","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology British Columbia Cancer Agency Centre for Lymphoid Cancer and the University of British Columbia Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Barrington","sequence":"additional","affiliation":[{"name":"PET Imaging Centre Division of Imaging Sciences and Biomedical Engineering King's College London King's Health Partners St. Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob W.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette 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