{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:18Z","timestamp":1789609218993,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Treatment of essential thrombocythaemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) is directed at decreasing the risk of complications of the disease, including arterial and venous thrombosis and bleeding episodes. Established risk factors for vascular events in patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> include advanced age (&gt;60\u00a0years) and prior history of thrombosis or haemorrhage. The role, if any, of other potential risk factors, including cardiovascular risk factors, leucocytosis, high haematocrit, and <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic> V617F has been analysed in multiple studies. The impact of thrombocytosis on the risk of vascular events has also been investigated. Many clinicians consider an elevated platelet count to be a risk factor for thrombosis or, when extreme, bleeding and utilize this as a criterion to start cytoreductive therapy. However, the relationship between thrombocytosis and vascular events is controversial and solid evidence to support the use of cytoreductive therapy in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients who have no other risk factors is lacking. In this review, we discuss current treatment recommendations for patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>, the biology underlying vascular events and risk factors thereof. We then review the evidence on the management of patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> and extreme thrombocytosis.<\/jats:p>","DOI":"10.1111\/bjh.14443","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T16:21:59Z","timestamp":1481991719000},"page":"352-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Approach to patients with essential thrombocythaemia and very high platelet counts: what is the evidence for treatment?"],"prefix":"10.1111","volume":"176","author":[{"given":"Lorenzo","family":"Falchi","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithviraj","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate J.","family":"Newberry","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdan","family":"Verstovsek","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404693"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-263319"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12321"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_12_6_1","first-page":"169","article-title":"Increased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status","volume":"91","author":"Arellano\u2010Rodrigo E.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8436"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-444067"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.94"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.337"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-478891"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401270"},{"key":"e_1_2_12_13_1","first-page":"160","article-title":"Risk factors for thrombohemorrhagic events and transformation events in 3649 Hig\u2010risk patients with essential thrombocythemia: results from the prospective long\u2010term observational EXELS study","volume":"100","author":"Birgeg\u00e5rd G.","year":"2015","journal-title":"Haematologica"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-424911"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153783"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-272179"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-339002"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12265"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.3.556"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321704"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12053"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13869"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05277.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4261"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.01.015"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.05.023"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.01.053"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002471"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614018"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.258"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12275"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12389"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050345"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2127.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24293"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537109777050"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043800"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08122.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1683-7"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000244"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02030.x"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2224-8"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880315)61:6<1207::AID-CNCR2820610625>3.0.CO;2-4"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.02.023"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000175153"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60486-8"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100600758677"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949664"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330106"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90491-U"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12256"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31820d94a5"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21360"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1154-3"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08858.x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.87"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21974"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-339655"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.06.032"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199711)56:3<168::AID-AJH6>3.0.CO;2-W"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-538983"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01021.x"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578435"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0058"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.863"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-025544"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21730"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23690"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13539"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7352265"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-064287"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv203"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.2.159"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:07:20Z","timestamp":1696352840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/bjh.14443"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14443","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]},"assertion":[{"value":"2016-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}