{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:19:37Z","timestamp":1789827577871,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["87"],"award-info":[{"award-number":["87"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Osteonecrosis is a well\u2010recognized complication in patients treated with corticosteroids. The incidence of osteonecrosis in children treated for Hodgkin lymphoma is unknown because prospective whole\u2010body magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) studies are lacking in this patient population. Paediatric patients with newly diagnosed Hodgkin lymphoma who were treated according to a uniform paediatric Hodgkin protocol were eligible for inclusion in this prospective study. Whole\u2010body <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> was performed in all 24 included patients (mean age 15\u00b71\u00a0years, 12 girls) both before treatment and after 2 cycles of chemotherapy, and in 16 patients after completion of chemotherapy. Osteonecrosis was identified in 10 patients (41\u00b77%, 95% confidence interval: 22\u00b70\u201361\u00b74%), with a total of 56 osteonecrotic sites. Osteonecrosis was detected in 8 patients after 2 cycles of <jats:styled-content style=\"fixed-case\">OEPA<\/jats:styled-content> (vincristine, etoposide, prednisone, doxorubicin), and in 2 additional patients after completion of chemotherapy. Epiphyseal involvement of long bones was seen in 4 of 10 children. None of the patients with osteonecrosis had any signs of bone collapse at the times of scanning. Whole\u2010body <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> demonstrates osteonecrosis to be a common finding occurring during therapy response assessment of paediatric Hodgkin lymphoma. Detection of early epiphyseal osteonecrosis could allow for treatment before bone collapse and joint damage may occur.<\/jats:p>","DOI":"10.1111\/bjh.14452","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T08:32:46Z","timestamp":1480321966000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Whole\u2010body <scp>MRI<\/scp> reveals high incidence of osteonecrosis in children treated for Hodgkin lymphoma"],"prefix":"10.1111","volume":"176","author":[{"given":"Annemieke S.","family":"Littooij","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht\u2010Princess Maxima Centre for Paediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Kwee","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht\u2010Princess Maxima Centre for Paediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goya","family":"Enr\u00edquez","sequence":"additional","affiliation":[{"name":"Department of Paediatric Radiology Hospital Materno\u2010Infantil Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I. 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