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The efficacy seen in relapsed\/refractory (r\/r) acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>), not only by inducing remission, but also in maintaining long\u2010term disease control, has been unprecedented. While the foundation for this approach has been firmly set in place, continued development will improve the efficacy, toxicity and applicability to other malignancies of this new class of \u2018living drugs\u2019. In this review, we provide a comprehensive overview of the most current clinical trial data in both acute and chronic leukaemias, and discuss some of the potential ways to enhance the activity and safety of <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> therapy going forward.<\/jats:p>","DOI":"10.1111\/bjh.14475","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T10:03:19Z","timestamp":1481968999000},"page":"13-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The promise of chimeric antigen receptor T cells (<scp>CART<\/scp>s) in leukaemia"],"prefix":"10.1111","volume":"177","author":[{"given":"Robert J.","family":"Orlowski","sequence":"first","affiliation":[{"name":"Department of Hematology\u2010Oncology University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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