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Red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) damage caused by continuous endogenous and exogenous oxidative stress may precipitate the occurrence of vaso\u2010occlusive crises. In order to gain insight into the relevance of oxidative stress in vaso\u2010occlusive crisis occurrence, we prospectively compared the expression levels of various oxidative markers in 32 adults with sickle cell anaemia during vaso\u2010occlusive crisis and steady\u2010state conditions. Compared to steady\u2010state condition, plasma levels of free haem, advanced oxidation protein products and myeloperoxidase,<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>caspase\u20103 activity, as well as the concentrations of total, neutrophil\u2010 and<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010derived microparticles were increased during vaso\u2010occlusive crises, whereas the reduced glutathione content was decreased in<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s. In addition, natural anti\u2010band 3 autoantibodies levels decreased during crisis and were negatively correlated with the rise in plasma advanced oxidation protein products and<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>caspase\u20103 activity. These data showed an exacerbation of the oxidative stress during vaso\u2010occlusive crises in sickle cell anaemia patients and strongly suggest that the higher concentration of harmful circulating<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010derived microparticles and the reduced anti\u2010band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates.<\/jats:p>","DOI":"10.1111\/bjh.14476","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T16:24:23Z","timestamp":1481991863000},"page":"805-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Exacerbation of oxidative stress during sickle vaso\u2010occlusive crisis is associated with decreased anti\u2010band 3 autoantibodies rate and increased red blood cell\u2010derived microparticle level: a prospective 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