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However, the optimal induction regimen is widely debated. The Southwestern Oncology Group S1106 trial was designed to assess rituximab plus hyper<jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ARAC<\/jats:styled-content> (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone, alternating with high dose cytarabine and methotrexate) (<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) <jats:italic>versus<\/jats:italic> rituximab plus bendamustine (<jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content>) in a randomized phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> trial to select a pre\u2010transplant induction regimen for future development. Patients had previously untreated stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IV<\/jats:styled-content>, or bulky stage <jats:styled-content style=\"fixed-case\">II MCL<\/jats:styled-content> and received either 4 cycles of <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> or 6 cycles of <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content>, followed by auto\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. Fifty\u2010three of a planned 160 patients were accrued; an unacceptably high mobilization failure rate (29%) on the <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> arm prompted premature study closure. The estimated 2\u2010year progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) was 81% vs. 82% and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was 87% vs. 88% for <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>, respectively. <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> is not an ideal platform for future multi\u2010centre transplant trials in <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> achieved a 2\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> of 81% and a 78% <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> negative rate. Premature closure of the study limited the sample size and the precision of <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> estimates and <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> rates. However, <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> can achieve a deep remission and could be a platform for future trials in <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14480","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T13:33:37Z","timestamp":1482154417000},"page":"759-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<scp>RB<\/scp> but not R\u2010<scp>HCVAD<\/scp> is a feasible induction regimen prior to auto\u2010<scp>HCT<\/scp> in frontline <scp>MCL<\/scp>: results of <scp>SWOG<\/scp> Study S1106"],"prefix":"10.1111","volume":"176","author":[{"given":"Robert W.","family":"Chen","sequence":"first","affiliation":[{"name":"City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Li","sequence":"additional","affiliation":[{"name":"SWOG Statistical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"James P. Wilmot Cancer Center University of Rochester School of Medicine and Dentistry Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Kahwash","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Rimsza","sequence":"additional","affiliation":[{"name":"University of Arizona Tucson AZ (previous) USA"},{"name":"Mayo Clinic Scottsdale AZ (current) USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology and HCT City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Constine","sequence":"additional","affiliation":[{"name":"University of Rochester James P. Wilmot Cancer Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Shea","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology UNC School of Medicine Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda F.","family":"Cashen","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Medicine Washington University School of Medicine Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie A.","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Hematology Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Fenske","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Barr","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tycel","family":"Phillips","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leblanc","sequence":"additional","affiliation":[{"name":"SWOG Statistical Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center\/Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Cheson","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali M.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Faham","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies Corp South San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies Corp South San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad S.","family":"Kahl","sequence":"additional","affiliation":[{"name":"University of Wisconsin Madison (previous) WI USA"},{"name":"Washington University School of Medicine in St. Louis St. Louis MO (current) USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt070"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11267"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1182\/blood.V81.5.1137.1137","article-title":"The place of high\u2010dose BEAM therapy and autologous bone marrow transplantation in poor\u2010risk hodgkin's disease. 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