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The majority of<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>patients have somatic mutations and\/or structural chromosomal abnormalities detected as early as at diagnosis. In contrast to other conditions linked to clonal haematopoiesis, the clonal signature of<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>reflects its immune pathophysiology. The most common alterations are clonal expansions of cells lacking glycophosphotidylinositol\u2010anchored proteins, loss of human leucocyte antigen alleles, and mutations in<jats:italic><jats:styled-content style=\"fixed-case\">BCOR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">BCORL<\/jats:styled-content>1<\/jats:italic>,<jats:italic><jats:styled-content style=\"fixed-case\">ASXL<\/jats:styled-content>1<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3A<\/jats:italic>. Here, we present the current knowledge of clonal haematopoiesis in<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>as it relates to aging, inherited bone marrow failure, and the grey\u2010zone overlap of<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>and myelodysplastic syndrome (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>). We conclude by discussing the significance of clonal haematopoiesis both for improved diagnosis of<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>, as well as for a more precise, personalized approach to prognostication of outcomes and therapy choices.<\/jats:p>","DOI":"10.1111\/bjh.14510","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T21:55:26Z","timestamp":1484949326000},"page":"509-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Recent advances in understanding clonal haematopoiesis in aplastic anaemia"],"prefix":"10.1111","volume":"177","author":[{"given":"Natasha","family":"Stanley","sequence":"first","affiliation":[{"name":"Comprehensive Bone Marrow Failure Center Division of Hematology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Olson","sequence":"additional","affiliation":[{"name":"Comprehensive Bone Marrow Failure Center Division of Hematology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia PA USA"},{"name":"Blood and Marrow Transplant Program Division of Oncology Department of Pediatrics Children's Hospital of Philadelphia and University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria V.","family":"Babushok","sequence":"additional","affiliation":[{"name":"Comprehensive Bone Marrow Failure Center Division of Hematology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia PA USA"},{"name":"Division of Hematology Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111199"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0822"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-314393"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08212.x"},{"key":"e_1_2_12_6_1","first-page":"1134","article-title":"Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia","volume":"15","author":"Appelbaum F.R.","year":"1987","journal-title":"Experimental Hematology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12603"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.01.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1509703"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1115041"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1182\/blood.V95.6.1931","article-title":"Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony\u2010stimulating factor for severe aplastic anemia: an update of the GITMO\/EBMT study on 100 patients. 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