{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:04:13Z","timestamp":1773680653809,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Advanced stage nodular lymphocyte predominant Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">nLPHL<\/jats:styled-content>) is extremely rare in children and as a consequence, optimal treatment for this group of patients has not been established. Here we retrospectively evaluated the treatments and treatment outcomes of 41 of our patients from the UK and France with advanced stage <jats:styled-content style=\"fixed-case\">nLPHL<\/jats:styled-content>. Most patients received chemotherapy, some with the addition of the anti <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 antibody rituximab or radiotherapy. Chemotherapy regimens were diverse and followed either classical Hodgkin lymphoma or B non\u2010Hodgkin lymphoma protocols. All 41 patients achieved a complete remission with first line treatment and 40 patients are alive and well in remission. Eight patients subsequently relapsed and 1 patient died of secondary cancer (9 progression\u2010free survival events). The median time to progression for those who progressed was 21\u00a0months (5\u00b79\u201373\u00b78). The median time since last diagnosis is 87\u00b73\u00a0months (8\u00b744\u2013179\u00b720). Thirty\u2010six (90%), 30 (75%) and 27 (68%) patients have been in remission for more than 12, 24 and 36\u00a0months, respectively. Overall, the use of rituximab combined with multi\u2010agent chemotherapy as first line treatment seems to be a reasonable therapeutic option.<\/jats:p>","DOI":"10.1111\/bjh.14518","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T17:13:51Z","timestamp":1487697231000},"page":"106-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Advanced stage nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents: clinical characteristics and treatment outcome \u2013 a report from the <scp>SFCE<\/scp> &amp; <scp>CCLG<\/scp> groups"],"prefix":"10.1111","volume":"177","author":[{"given":"Ananth G.","family":"Shankar","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adolescent Oncology University College London Hospitals NHS Foundation Trust  London 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