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Thus, it is not strange that this pathway is often deregulated in haematological tumours, providing a strong preclinical rationale for the use of drugs targeting the <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u2010<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> axis in haematological malignancies. The main focus of this review is to examine the mammalian target of rapamycin (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>, also termed mechanistic target of rapamycin [<jats:styled-content style=\"fixed-case\">MTOR<\/jats:styled-content>]) signalling pathways and to provide a brief overview of rapalogs and second\u2010generation <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitors used to target its aberrant activation in cancer treatment. We will also discuss the results obtained with the use of these agents in patients with acute leukaemia, Hodgkin lymphoma, non\u2010Hodgkin lymphomas, multiple myeloma and Waldenstr\u00f6m macroglobulinaemia. Ongoing clinical trials in haematological malignancies that are investigating first\u2010 and second\u2010generation <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitors as single agents and as components of combination regimens are also presented.<\/jats:p>","DOI":"10.1111\/bjh.14529","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T16:12:59Z","timestamp":1485965579000},"page":"684-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["m\u2010<scp>TOR<\/scp> inhibitors and their potential role in haematological malignancies"],"prefix":"10.1111","volume":"177","author":[{"given":"Teresa","family":"Calimeri","sequence":"first","affiliation":[{"name":"Unit of Lymphoid Malignancies Department of Onco\u2010Haematology IRCCS San Raffaele Scientific Institute Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J. 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